Side effects to levamisole given to neoplastic patients as adjuvant to surgery: A new case of agranulocytosis

S. Colizza, P. Bagolan, M. Di Paola

Research output: Contribution to journalArticle

Abstract

Side-effects to levamisole given as adjuvant to surgery in a consecutive series of 203 neoplastic patients are reported: Thirty-four patients (16.7%) suffered gastric adverse reactions; 8 (3.9%) allergic; 6 (2.9%) intestinal; 6 (2.9% neurologic; 4 (1.9%) severe hyperthermia (more than 40.5°C); 3 (1.4%) flu-like illness; 1 (0.4%) leucopenia; and 1 (0.4%) agranulocytosis. Withdrawal rate was 5.4% or 11 patients. Side effects appeared sex-related (39.0% in females, 17.7% in males; with seven female dropouts out of 11), unrelated to other eventual adjuvant treatments, and reappearing at a new challenge with levamisole. The opportunity of very close control of patients taking levamisole for at least the first months is discussed.

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalJournal of Surgical Oncology
Volume16
Issue number3
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Oncology
  • Surgery

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