Abstract
Angiogenesis plays a key role in tumour growth and the formation of metastases. Angiogenesis inhibitors and antivascular agents may prove useful in the treatment of breast cancer. A comprehensive characterization of the vasculature and perfusion of mammary tumours is a prerequisite for developing new specific drugs. We used sidestream dark field videomicroscopy to evaluate in vivo the vascular network of spontaneous mammary tumours in HER2/neu transgenic mice. The tumour masses showed higher vessel density compared with the healthy mammary gland (median (interquartile range) total vessel density 16.8 (13.4-20.5) vs 9.1 (8.1-10.9) mm/mm2, respectively; P 2. Sidestream dark field imaging is a versatile technique that may be useful for understanding the role of angiogenesis in the progression of breast cancer and its relationship with outcome. It may represent a valuable tool for dynamic monitoring of the effects of new anti-angiogenesis therapies.
Original language | English |
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Pages (from-to) | 225-229 |
Number of pages | 5 |
Journal | Clinical and Experimental Pharmacology and Physiology |
Volume | 42 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 1 2015 |
Keywords
- Angiogenesis
- Breast cancer
- Sidestream dark field videomicroscopy
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
- Pharmacology
- Medicine(all)