Sigh in Patients With Acute Hypoxemic Respiratory Failure and ARDS: The PROTECTION Pilot Randomized Clinical Trial

The PROTECTION Trial Collaborators, T. Mauri, G. Foti, C. Fornari, G. Grasselli, R. Pinciroli, F. Lovisari, D. Tubiolo, C.A. Volta, S. Spadaro, R. Rona, E. Rondelli, P. Navalesi, E. Garofalo, R. Knafelj, V. Gorjup, R. Colombo, A. Cortegiani, J.-X. Zhou, R. D'AndreaI. Calamai, Á.V. González, O. Roca, D.L. Grieco, T. Jovaisa, D. Bampalis, T. Becher, D. Battaglini, H. Ge, M. Luz, J.-M. Constantin, M. Ranieri, C. Guerin, J. Mancebo, P. Pelosi, R. Fumagalli, L. Brochard, A. Pesenti

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1426-1436
Number of pages11
Issue number4
Publication statusPublished - 2021


  • ARDS
  • feasibility
  • pressure support
  • sigh
  • ventilation
  • acute respiratory failure
  • adult
  • adult respiratory distress syndrome
  • adverse event
  • aged
  • airway pressure
  • Article
  • breathing rate
  • clinical outcome
  • comparative study
  • controlled study
  • death
  • feasibility study
  • female
  • human
  • incidence
  • intubation
  • lung minute volume
  • major clinical study
  • male
  • mortality rate
  • multicenter study
  • oxygenation
  • patient safety
  • pilot study
  • positive pressure ventilation
  • pressure support ventilation
  • priority journal
  • randomized controlled trial
  • tidal volume

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