Signal intensity change on unenhanced T1-weighted images in dentate nucleus and globus pallidus after multiple administrations of gadoxetate disodium: an intraindividual comparative study

Giorgio Conte, Lorenzo Preda, Emilia Cocorocchio, Sara Raimondi, Caterina Giannitto, Marta Minotti, Francesca De Piano, Giuseppe Petralia, Pier Francesco Ferrucci, Massimo Bellomi

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Abstract

Purpose: To investigate whether there is an increased signal intensity (SI) of dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance imaging (MRI), in patients who had undergone multiple administrations of gadoxetate disodium. Materials and methods: We retrospectevely included stage III melanoma patients, who had been previously enrolled in a trial of adjuvant therapy and who had undergone whole-body contrast-enhanced MRIs with gadoxetate disodium every three months for their follow-up. The SI ratios of DN-to-pons and GP-to-thalamus on unenhanced T1-weighted images were calculated. The difference in SI ratios between the first and the last MRI examinations was assessed and a linear mixed model was performed to detect how SI ratios varied with the number of administrations. Results: Eighteen patients were included in our study. The number of gadoxetate disodium administrations ranged from 2 to 18. Paired t-test did not show any significant difference in DN-to-pons (p=0.21) and GP-to-thalamus (p=0.09) SI ratios by the end of the study. DN-to-pons SI ratio and GP-to-thalamus SI ratio did not significantly increase with increasing the number of administrations (p=0.14 and p=0.06, respectively). Conclusion: Multiple administrations of gadoxetate disodium are not associated with increased SI in DN and GP in the brain. Key Points: • Gadolinium may deposit in the human brain after multiple GBCA administrations. • Gadolinium deposition is associated with increased T1W signal intensity • Increase in signal intensity is most apparent within the DN and GP • Multiple administrations of gadoxetate disodium do not increase T1W signal.

Original languageEnglish
Pages (from-to)4372-4378
Number of pages7
JournalEuropean Radiology
Volume27
Issue number10
DOIs
Publication statusPublished - Oct 1 2017

Fingerprint

Cerebellar Nuclei
Globus Pallidus
Pons
Thalamus
Gadolinium
Magnetic Resonance Imaging
Brain
gadolinium ethoxybenzyl DTPA
Linear Models
Melanoma

Keywords

  • Dentate nucleus
  • Gadolinium
  • Gadoxetate disodium
  • Globus pallidus
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{edd620fdf4a14c61b942bf4088263937,
title = "Signal intensity change on unenhanced T1-weighted images in dentate nucleus and globus pallidus after multiple administrations of gadoxetate disodium: an intraindividual comparative study",
abstract = "Purpose: To investigate whether there is an increased signal intensity (SI) of dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance imaging (MRI), in patients who had undergone multiple administrations of gadoxetate disodium. Materials and methods: We retrospectevely included stage III melanoma patients, who had been previously enrolled in a trial of adjuvant therapy and who had undergone whole-body contrast-enhanced MRIs with gadoxetate disodium every three months for their follow-up. The SI ratios of DN-to-pons and GP-to-thalamus on unenhanced T1-weighted images were calculated. The difference in SI ratios between the first and the last MRI examinations was assessed and a linear mixed model was performed to detect how SI ratios varied with the number of administrations. Results: Eighteen patients were included in our study. The number of gadoxetate disodium administrations ranged from 2 to 18. Paired t-test did not show any significant difference in DN-to-pons (p=0.21) and GP-to-thalamus (p=0.09) SI ratios by the end of the study. DN-to-pons SI ratio and GP-to-thalamus SI ratio did not significantly increase with increasing the number of administrations (p=0.14 and p=0.06, respectively). Conclusion: Multiple administrations of gadoxetate disodium are not associated with increased SI in DN and GP in the brain. Key Points: • Gadolinium may deposit in the human brain after multiple GBCA administrations. • Gadolinium deposition is associated with increased T1W signal intensity • Increase in signal intensity is most apparent within the DN and GP • Multiple administrations of gadoxetate disodium do not increase T1W signal.",
keywords = "Dentate nucleus, Gadolinium, Gadoxetate disodium, Globus pallidus, Magnetic resonance imaging",
author = "Giorgio Conte and Lorenzo Preda and Emilia Cocorocchio and Sara Raimondi and Caterina Giannitto and Marta Minotti and {De Piano}, Francesca and Giuseppe Petralia and Ferrucci, {Pier Francesco} and Massimo Bellomi",
year = "2017",
month = "10",
day = "1",
doi = "10.1007/s00330-017-4810-3",
language = "English",
volume = "27",
pages = "4372--4378",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "10",

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TY - JOUR

T1 - Signal intensity change on unenhanced T1-weighted images in dentate nucleus and globus pallidus after multiple administrations of gadoxetate disodium

T2 - an intraindividual comparative study

AU - Conte, Giorgio

AU - Preda, Lorenzo

AU - Cocorocchio, Emilia

AU - Raimondi, Sara

AU - Giannitto, Caterina

AU - Minotti, Marta

AU - De Piano, Francesca

AU - Petralia, Giuseppe

AU - Ferrucci, Pier Francesco

AU - Bellomi, Massimo

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Purpose: To investigate whether there is an increased signal intensity (SI) of dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance imaging (MRI), in patients who had undergone multiple administrations of gadoxetate disodium. Materials and methods: We retrospectevely included stage III melanoma patients, who had been previously enrolled in a trial of adjuvant therapy and who had undergone whole-body contrast-enhanced MRIs with gadoxetate disodium every three months for their follow-up. The SI ratios of DN-to-pons and GP-to-thalamus on unenhanced T1-weighted images were calculated. The difference in SI ratios between the first and the last MRI examinations was assessed and a linear mixed model was performed to detect how SI ratios varied with the number of administrations. Results: Eighteen patients were included in our study. The number of gadoxetate disodium administrations ranged from 2 to 18. Paired t-test did not show any significant difference in DN-to-pons (p=0.21) and GP-to-thalamus (p=0.09) SI ratios by the end of the study. DN-to-pons SI ratio and GP-to-thalamus SI ratio did not significantly increase with increasing the number of administrations (p=0.14 and p=0.06, respectively). Conclusion: Multiple administrations of gadoxetate disodium are not associated with increased SI in DN and GP in the brain. Key Points: • Gadolinium may deposit in the human brain after multiple GBCA administrations. • Gadolinium deposition is associated with increased T1W signal intensity • Increase in signal intensity is most apparent within the DN and GP • Multiple administrations of gadoxetate disodium do not increase T1W signal.

AB - Purpose: To investigate whether there is an increased signal intensity (SI) of dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance imaging (MRI), in patients who had undergone multiple administrations of gadoxetate disodium. Materials and methods: We retrospectevely included stage III melanoma patients, who had been previously enrolled in a trial of adjuvant therapy and who had undergone whole-body contrast-enhanced MRIs with gadoxetate disodium every three months for their follow-up. The SI ratios of DN-to-pons and GP-to-thalamus on unenhanced T1-weighted images were calculated. The difference in SI ratios between the first and the last MRI examinations was assessed and a linear mixed model was performed to detect how SI ratios varied with the number of administrations. Results: Eighteen patients were included in our study. The number of gadoxetate disodium administrations ranged from 2 to 18. Paired t-test did not show any significant difference in DN-to-pons (p=0.21) and GP-to-thalamus (p=0.09) SI ratios by the end of the study. DN-to-pons SI ratio and GP-to-thalamus SI ratio did not significantly increase with increasing the number of administrations (p=0.14 and p=0.06, respectively). Conclusion: Multiple administrations of gadoxetate disodium are not associated with increased SI in DN and GP in the brain. Key Points: • Gadolinium may deposit in the human brain after multiple GBCA administrations. • Gadolinium deposition is associated with increased T1W signal intensity • Increase in signal intensity is most apparent within the DN and GP • Multiple administrations of gadoxetate disodium do not increase T1W signal.

KW - Dentate nucleus

KW - Gadolinium

KW - Gadoxetate disodium

KW - Globus pallidus

KW - Magnetic resonance imaging

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