Signaling Circuits on the Golgi Complex

Jorge Cancino, Alberto Luini

Research output: Contribution to journalArticle

Abstract

Numerous components of signaling pathways involved in key cellular processes reside on the Golgi complex. Here, we will focus on the roles of signaling proteins that regulate cargo trafficking along the anterograde and retrograde pathways. Emphasis will also be put on the effects of these regulatory proteins on the maintenance of the structure and function of the Golgi, and in particular on the phosphorylation of key components of the transport machinery. These pathways position the Golgi complex as a central hub in the regulation of cell signaling. To date, however, the activation and coordination of these signaling molecules remain a mystery. Being able to describe the interplay between several of these signaling pathways and secretion, and the flow of information through these pathways, will help us to understand how the secretory machinery works and how it interacts with other cellular functions. This will also advance our understanding of how the secretory pathway functions under physiological circumstances, and how its dysregulation can initiate pathological conditions.

Original languageEnglish
Pages (from-to)121-134
Number of pages14
JournalTraffic
Volume14
Issue number2
DOIs
Publication statusPublished - Feb 2013

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Keywords

  • Cell signaling
  • G-protein
  • Golgi complex
  • Kinase

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Structural Biology
  • Molecular Biology
  • Genetics

Cite this

Cancino, J., & Luini, A. (2013). Signaling Circuits on the Golgi Complex. Traffic, 14(2), 121-134. https://doi.org/10.1111/tra.12022