Signaling networks associated with AKT activation in non-small cell lung cancer (NSCLC): New insights on the role of phosphatydil-inositol-3 kinase

Marianna Scrima, Carmela de Marco, Fernanda Fabiani, Renato Franco, Giuseppe Pirozzi, Gaetano Rocco, Maria Ravo, Alessandro Weisz, Pietro Zoppoli, Michele Ceccarelli, Gerardo Botti, Donatella Malanga, Giuseppe Viglietto

Research output: Contribution to journalArticlepeer-review

Abstract

Aberrant activation of PI3K/AKT signalling represents one of the most common molecular alterations in lung cancer, though the relative contribution of the single components of the cascade to the NSCLC development is still poorly defined. In this manuscript we have investigated the relationship between expression and genetic alterations of the components of the PI3K/AKT pathway [KRAS, the catalytic subunit of PI3K (p110α), PTEN, AKT1 and AKT2] and the activation of AKT in 107 surgically resected NSCLCs and have analyzed the existing relationships with clinico-pathologic features. Expression analysis was performed by immunohistochemistry on Tissue Micro Arrays (TMA); mutation analysis was performed by DNA sequencing; copy number variation was determined by FISH. We report that activation of PI3K/AKT pathway in Italian NSCLC patients is associated with high grade (G3-G4 compared with G1-G2; n = 83; p

Original languageEnglish
Article numbere30427
JournalPLoS One
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 17 2012

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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