Signaling pathways activated by chemokine receptor CXCR2 and AMPA-type glutamate receptors and involvement in granule cells survival

C. Limatola, M. T. Ciotti, D. Mercanti, A. Santoni, F. Eusebi

Research output: Contribution to journalArticlepeer-review

Abstract

We show that treatment of cerebellar granules with interleukin-8 (IL-8), growth-related gene product β (GROβ) or AMPA induced activation of PI3-K/Akt and of ERK pathways, the latter being independent of PI3-K and dependent on PTX-sensitive G proteins. We also show that AMPA-mediated neuron survival was abolished both by ERK kinase inhibitor PD98059 and AMPA-Rs blocker CNQX, and that chemokine-mediated survival was blocked by the PI3-K inhibitors LY294002 and wortmannin. We conclude that the neurotrophic effects of AMPA need the contemporary activation of ERKs and stimulation of AMPA-Rs, and that PI3-K/Akt activation is a determinant pathway for the IL-8/GROβ anti-apoptotic activity.

Original languageEnglish
Pages (from-to)9-17
Number of pages9
JournalJournal of Neuroimmunology
Volume123
Issue number1-2
DOIs
Publication statusPublished - 2002

Keywords

  • Akt
  • CNQX
  • ERK
  • Neurotrophic
  • PI3-K

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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