Signaling routes to CREM and CREB: Plasticity in transcriptional activation

Dario De Cesare, Gian Maria Fimia, Paolo Sassone-Corsi

Research output: Contribution to journalArticlepeer-review


The CREB and CREM transcription factors are activated by phosphorylation of a key serine residue by kinases stimulated by cyclic AMP, Ca2+, growth factors and stress signals. Phosphorylation allows recruitment of CREB-binding protein (CBP), a large co-activator that contacts the general transcriptional machinery. Studies of the physiological roles played by CREB and CREM have uncovered novel routes of transcriptional activation. For example, in male germ cells CREM is not phosphorylated but associates with ACT, a member of the LIM-only class of proteins that has intrinsic transcriptional activity. Thus, in some circumstances, CREM can bypass the classical requirement for phosphorylation and association with CBP. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)281-285
Number of pages5
JournalTrends in Biochemical Sciences
Issue number7
Publication statusPublished - Jul 1 1999

ASJC Scopus subject areas

  • Biochemistry


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