Signalling by proteolysis: Death receptors induce apoptosis

Research output: Contribution to journalArticlepeer-review

Abstract

Apoptosis, or programmed cell death, is a genetically regulated mechanism with a central role in both metazoan development and homeostasis. Death receptors (Fas, TNFR-2, DR3, and TRAIL receptors) induce apoptosis upon ligation to cognate ligands or ectopic expression. The assembly of a death-inducing signalling complex occurs in a hierarchical manner upon receptor activation. The death domain of the receptor binds to the corresponding domain of the adapter molecule FADD, which in turn recruits the zymogen form of the death protease FLICE (MACH/caspase-8). Upon approximation, FLICE 'zymogens' attain a sufficient concentration to self-activate and to trigger the apoptotic pathway. For the first time, a transmembrane receptor directly engaging a protease at the signalling complex and subsequently triggering a proteolytic signalling cascade is described.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalInternational Journal of Clinical & Laboratory Research
Volume28
Issue number3
DOIs
Publication statusPublished - Sep 1998

Keywords

  • Apo
  • Apoptosis
  • Caspase
  • Signalling
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Clinical Biochemistry

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