Signals from the Niche: Insights into the Role of IGF-1 and IL-6 in Modulating Skeletal Muscle Fibrosis

Laura Forcina, Carmen Miano, Bianca Maria Scicchitano, Antonio Musarò

Research output: Contribution to journalReview article

Abstract

Muscle regeneration, characterized by the activation and proliferation of satellite cells and other precursors, is accompanied by an inflammatory response and the remodeling of the extracellular matrix (ECM), necessary to remove cellular debris and to mechanically support newly generated myofibers and activated satellite cells. Muscle repair can be considered concluded when the tissue architecture, vascularization, and innervation have been restored. Alterations in these connected mechanisms can impair muscle regeneration, leading to the replacement of functional muscle tissue with a fibrotic scar. In the present review, we will discuss the cellular mediators of fibrosis and how the altered expression and secretion of soluble mediators, such as IL-6 and IGF-1, can modulate regulatory networks involved in the altered regeneration and fibrosis during aging and diseases.

Original languageEnglish
JournalCells
Volume8
Issue number3
DOIs
Publication statusPublished - Mar 11 2019

Keywords

  • Animals
  • Fibrosis
  • Humans
  • Insulin-Like Growth Factor I/metabolism
  • Interleukin-6/metabolism
  • Muscle, Skeletal/metabolism
  • Regeneration
  • Signal Transduction

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