Abstract
Background: International Neuroblastoma Staging System (INSS) Stage 3 neuroblastoma is a heterogeneous disease. Data from the International Neuroblastoma Risk Group (INRG) database were analyzed to define patient and tumor characteristics predictive of outcome. Procedure: Of 8,800 patients in the INRG database, 1,483 with INSS Stage 3 neuroblastoma and complete follow-up data were analyzed. Secondary analysis was performed in 1,013 patients (68%) with MYCN-non-amplified (NA) tumors. Significant prognostic factors were identified via log-rank test comparisons of survival curves. Multivariable Cox proportional hazards regression model was used to identify factors independently predictive of event-free survival (EFS). Results: Age at diagnosis (P
Original language | English |
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Pages (from-to) | 1932-1939 |
Number of pages | 8 |
Journal | Pediatric Blood and Cancer |
Volume | 61 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 1 2014 |
Keywords
- Biologic factor
- Neuroblastoma
- Treatment outcome
ASJC Scopus subject areas
- Oncology
- Pediatrics, Perinatology, and Child Health
- Hematology