Significance of cyclin D1 expression in meningiomas: A preliminary study

Angela Alama, Federica Barbieri, Renato Spaziante, Cristina Bruzzo, Patrizia Dadati, Alessandra Dorcaratto, Jean Louis Ravetti

Research output: Contribution to journalArticle

Abstract

Forty-four evaluable patients with intracranial meningiomas were assessed for the expression of the cell-cycle regulator cyclin D1 and of proteins involved in proliferation and apoptosis such as PCNA, MIB-1, p53 and bcl-2. Analyses were carried out by western blot and immunohistochemistry after immediate processing of fresh tumor specimens. By western blot, expression of cyclin D1 significantly correlated with p53 (p = 0.02) and with proliferative activity, as assessed by PCNA expression (p = 0.0009). By immunohistochemistry, a significant relationship between cyclin D1 and the proliferation marker MIB-1 was confirmed (p = 0.05), whereas significance with bcl-2 expression was not found (p = 0.01). Moreover, although the association with tumor grade appeared of borderline statistical significance (p = 0.07), all the grade II/III meningiomas showed increased expression of cyclin D1 and high proliferative activity. In conclusion, data from this preliminary study seem to suggest a potential value of the combined expression of cyclin D1 and proliferation indicators in defining subgroups of meningiomas with a more aggressive biological behavior.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalJournal of Clinical Neuroscience
Volume14
Issue number4
DOIs
Publication statusPublished - Apr 2007

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Cyclin D1
Meningioma
Proliferating Cell Nuclear Antigen
Western Blotting
Immunohistochemistry
Neoplasms
Cell Cycle
Apoptosis
Proteins

Keywords

  • Cyclin D1
  • Intracranial meningioma
  • Proliferation markers

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology

Cite this

Alama, A., Barbieri, F., Spaziante, R., Bruzzo, C., Dadati, P., Dorcaratto, A., & Ravetti, J. L. (2007). Significance of cyclin D1 expression in meningiomas: A preliminary study. Journal of Clinical Neuroscience, 14(4), 355-358. https://doi.org/10.1016/j.jocn.2006.04.001

Significance of cyclin D1 expression in meningiomas : A preliminary study. / Alama, Angela; Barbieri, Federica; Spaziante, Renato; Bruzzo, Cristina; Dadati, Patrizia; Dorcaratto, Alessandra; Ravetti, Jean Louis.

In: Journal of Clinical Neuroscience, Vol. 14, No. 4, 04.2007, p. 355-358.

Research output: Contribution to journalArticle

Alama, A, Barbieri, F, Spaziante, R, Bruzzo, C, Dadati, P, Dorcaratto, A & Ravetti, JL 2007, 'Significance of cyclin D1 expression in meningiomas: A preliminary study', Journal of Clinical Neuroscience, vol. 14, no. 4, pp. 355-358. https://doi.org/10.1016/j.jocn.2006.04.001
Alama, Angela ; Barbieri, Federica ; Spaziante, Renato ; Bruzzo, Cristina ; Dadati, Patrizia ; Dorcaratto, Alessandra ; Ravetti, Jean Louis. / Significance of cyclin D1 expression in meningiomas : A preliminary study. In: Journal of Clinical Neuroscience. 2007 ; Vol. 14, No. 4. pp. 355-358.
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