Significance of hepatic expression of hepatitis C viral antigens in chronic hepatitis C

Regino P. González-Peralta, Jane W S Fang, Gary L. Davis, Robert G. Gish, Michinori Kohara, Mario U. Mondelli, Mickey S. Urdea, Masashi Mizokami, Johnson Y N Lau

Research output: Contribution to journalArticlepeer-review

Abstract

To determine the significance of hepatic expression of hepatitis C viral (HCV) antigens, HCV core and NS4 antigens were detected by immunohistochemistry in 46 patients with chronic HCV infection. Serum HCV RNA was quantitated by branched DNA assay in 41 and HCV genotype determined in 30 patients. HCV core and NS4 antigens were detected exclusively in the cytoplasm of hepatocytes in 83% and 61% of patients, respectively. There was no correlation between the expression of HCV antigens and clinical, biochemical, histological parameters and HCV genotype. Hepatic expression of HCV antigens was positively associated with serum HCV-RNA levels (P

Original languageEnglish
Pages (from-to)2595-2601
Number of pages7
JournalDigestive Diseases and Sciences
Volume40
Issue number12
DOIs
Publication statusPublished - Dec 1995

Keywords

  • antigens
  • core
  • genotype
  • HCV
  • immunohistochemistry
  • interferon
  • NS4

ASJC Scopus subject areas

  • Gastroenterology

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