Significance of IgM anti-HCV in chronic hepatitis C patients-treated by daily interferon regimen

F. Zara, M. Debiaggi, R. Bruno, E. Maffezzini, A. Pistorio, R. Brerra, M. G. Ferrari, E. Fasani, E. Romero, G. Filice

Research output: Contribution to journalArticle

Abstract

Objectives: To assess if detection of IgM anti-HCV is correlated with HCV-replication, genotype, histological activity and effects of daily α-IFN regimen on HCV production. Patients and methods: We evaluated serum biochemical and virological profiles and liver histology in a cohort of 22 patients with chronic hepatitis C treated with 3 mega units of IFN α-2a daily/dose for at least 12 months. Results: All 22 patients with chronic hepatitis C had HCV IgG antibodies. IgM anti-HCV were detected in 15 cases (68.1%). All 22 patients were HCV-RNA positive; although mean HCV-RNA titers were higher in IgM positive than IgM negative patients, they did not differ significantly. At month 18 a sustained biochemical and virological response was observed in 7/22 (31.8%) and was more frequent in IgM negative than IgM positive patients (p=0.08 and p

Original languageEnglish
Pages (from-to)144-148
Number of pages5
JournalGiornale Italiano di Malattie Infettive
Volume6
Issue number3
Publication statusPublished - 2000

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Keywords

  • Chronic hepatitis
  • Daily interferon regimen
  • IgM anti-HCV

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Zara, F., Debiaggi, M., Bruno, R., Maffezzini, E., Pistorio, A., Brerra, R., Ferrari, M. G., Fasani, E., Romero, E., & Filice, G. (2000). Significance of IgM anti-HCV in chronic hepatitis C patients-treated by daily interferon regimen. Giornale Italiano di Malattie Infettive, 6(3), 144-148.