Significance of IgM anti-HCV in chronic hepatitis C patients-treated by daily interferon regimen

F. Zara; M. Debiaggi; R. Bruno; E. Maffezzini; A. Pistorio; R. Brerra; M. G. Ferrari; E. Fasani; E. Romero; G. Filice

Significance of IgM anti-HCV in chronic hepatitis C patients-treated by daily interferon regimen

F. Zara, M. Debiaggi, R. Bruno, E. Maffezzini, A. Pistorio, R. Brerra, M. G. Ferrari, E. Fasani, E. Romero, G. Filice

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Abstract

Objectives: To assess if detection of IgM anti-HCV is correlated with HCV-replication, genotype, histological activity and effects of daily α-IFN regimen on HCV production. Patients and methods: We evaluated serum biochemical and virological profiles and liver histology in a cohort of 22 patients with chronic hepatitis C treated with 3 mega units of IFN α-2a daily/dose for at least 12 months. Results: All 22 patients with chronic hepatitis C had HCV IgG antibodies. IgM anti-HCV were detected in 15 cases (68.1%). All 22 patients were HCV-RNA positive; although mean HCV-RNA titers were higher in IgM positive than IgM negative patients, they did not differ significantly. At month 18 a sustained biochemical and virological response was observed in 7/22 (31.8%) and was more frequent in IgM negative than IgM positive patients (p=0.08 and p

Original language	English
Pages (from-to)	144-148
Number of pages	5
Journal	Giornale Italiano di Malattie Infettive
Volume	6
Issue number	3
Publication status	Published - 2000

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Keywords

Chronic hepatitis
Daily interferon regimen
IgM anti-HCV

ASJC Scopus subject areas

Microbiology (medical)

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Zara, F., Debiaggi, M., Bruno, R., Maffezzini, E., Pistorio, A., Brerra, R., Ferrari, M. G., Fasani, E., Romero, E., & Filice, G. (2000). Significance of IgM anti-HCV in chronic hepatitis C patients-treated by daily interferon regimen. Giornale Italiano di Malattie Infettive, 6(3), 144-148.

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title = "Significance of IgM anti-HCV in chronic hepatitis C patients-treated by daily interferon regimen",

abstract = "Objectives: To assess if detection of IgM anti-HCV is correlated with HCV-replication, genotype, histological activity and effects of daily α-IFN regimen on HCV production. Patients and methods: We evaluated serum biochemical and virological profiles and liver histology in a cohort of 22 patients with chronic hepatitis C treated with 3 mega units of IFN α-2a daily/dose for at least 12 months. Results: All 22 patients with chronic hepatitis C had HCV IgG antibodies. IgM anti-HCV were detected in 15 cases (68.1%). All 22 patients were HCV-RNA positive; although mean HCV-RNA titers were higher in IgM positive than IgM negative patients, they did not differ significantly. At month 18 a sustained biochemical and virological response was observed in 7/22 (31.8%) and was more frequent in IgM negative than IgM positive patients (p=0.08 and p",

keywords = "Chronic hepatitis, Daily interferon regimen, IgM anti-HCV",

author = "F. Zara and M. Debiaggi and R. Bruno and E. Maffezzini and A. Pistorio and R. Brerra and Ferrari, {M. G.} and E. Fasani and E. Romero and G. Filice",

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language = "English",

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TY - JOUR

T1 - Significance of IgM anti-HCV in chronic hepatitis C patients-treated by daily interferon regimen

AU - Zara, F.

AU - Debiaggi, M.

AU - Bruno, R.

AU - Maffezzini, E.

AU - Pistorio, A.

AU - Brerra, R.

AU - Ferrari, M. G.

AU - Fasani, E.

AU - Romero, E.

AU - Filice, G.

PY - 2000

Y1 - 2000

N2 - Objectives: To assess if detection of IgM anti-HCV is correlated with HCV-replication, genotype, histological activity and effects of daily α-IFN regimen on HCV production. Patients and methods: We evaluated serum biochemical and virological profiles and liver histology in a cohort of 22 patients with chronic hepatitis C treated with 3 mega units of IFN α-2a daily/dose for at least 12 months. Results: All 22 patients with chronic hepatitis C had HCV IgG antibodies. IgM anti-HCV were detected in 15 cases (68.1%). All 22 patients were HCV-RNA positive; although mean HCV-RNA titers were higher in IgM positive than IgM negative patients, they did not differ significantly. At month 18 a sustained biochemical and virological response was observed in 7/22 (31.8%) and was more frequent in IgM negative than IgM positive patients (p=0.08 and p

AB - Objectives: To assess if detection of IgM anti-HCV is correlated with HCV-replication, genotype, histological activity and effects of daily α-IFN regimen on HCV production. Patients and methods: We evaluated serum biochemical and virological profiles and liver histology in a cohort of 22 patients with chronic hepatitis C treated with 3 mega units of IFN α-2a daily/dose for at least 12 months. Results: All 22 patients with chronic hepatitis C had HCV IgG antibodies. IgM anti-HCV were detected in 15 cases (68.1%). All 22 patients were HCV-RNA positive; although mean HCV-RNA titers were higher in IgM positive than IgM negative patients, they did not differ significantly. At month 18 a sustained biochemical and virological response was observed in 7/22 (31.8%) and was more frequent in IgM negative than IgM positive patients (p=0.08 and p

KW - Chronic hepatitis

KW - Daily interferon regimen

KW - IgM anti-HCV

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SN - 1126-9952

IS - 3

ER -

Significance of IgM anti-HCV in chronic hepatitis C patients-treated by daily interferon regimen

Abstract

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Keywords

ASJC Scopus subject areas

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