Abstract
Objectives: To assess if detection of IgM anti-HCV is correlated with HCV-replication, genotype, histological activity and effects of daily α-IFN regimen on HCV production. Patients and methods: We evaluated serum biochemical and virological profiles and liver histology in a cohort of 22 patients with chronic hepatitis C treated with 3 mega units of IFN α-2a daily/dose for at least 12 months. Results: All 22 patients with chronic hepatitis C had HCV IgG antibodies. IgM anti-HCV were detected in 15 cases (68.1%). All 22 patients were HCV-RNA positive; although mean HCV-RNA titers were higher in IgM positive than IgM negative patients, they did not differ significantly. At month 18 a sustained biochemical and virological response was observed in 7/22 (31.8%) and was more frequent in IgM negative than IgM positive patients (p=0.08 and p
Original language | English |
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Pages (from-to) | 144-148 |
Number of pages | 5 |
Journal | Giornale Italiano di Malattie Infettive |
Volume | 6 |
Issue number | 3 |
Publication status | Published - 2000 |
Keywords
- Chronic hepatitis
- Daily interferon regimen
- IgM anti-HCV
ASJC Scopus subject areas
- Microbiology (medical)