Significance of lymph node sampling in epithelial carcinoma of the ovary

Flavio Carnino, Giancarlo Fuda, Giovannino Ciccone, Lilliana Iskra, Elso Guercio, Domenico Dadone, Pier Franco Conte

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Abstract

From 1979 to 1984, 127 patients operated on for ovarian cancer underwent pelvic, para-aortic, or pelvic and para-aortic lymph node sampling. Forty- seven patients proved to be stage I (14 IA and 33 IC), 14 were stage II (3 IIA, 8 IIB, and 3 IIC), 58 were stage III (7 IIIA, 13 IIIB, and 38 IIIC), and 8 were stage IV. Positive lymph nodes were found in 4.2% of patients at stage 1, 35.7% at stage II, 41.3% at stage III, and 87.5% at stage IV. With regard to grading, positive lymph nodes were found in 4.4% of G1, in 21.6% of G2, and in 49.1% of G3. A significant increase in survival (P = 0.04) was found for patients classified as stage IIIC only according to lymph node involvement compared to patients in peritoneal stage IIIC with positive lymph nodes (3-year survival: 46% vs 12%). A small increase in survival was observed for N patients compared to N+ patients, at both stage III and IV, even with same residual tumor size, but the difference is not statistically significant. All other things being equal, because the prevalence of lymph node positivity depends closely on the number of lymph nodes removed and examined (OR = 3.9 for >10 lymph nodes removed compared to 1-5 lymph nodes removed), lymph node sampling does not seem to be a reliable method for evaluating the retroperitoneal status. With regard to the therapeutic role of systematic lymphadenectomy, few data in literature are available and, most important, are not derived from experimental studies. Probably, only randomized studies with a large number of patients will provide useful answers.

Original languageEnglish
Pages (from-to)467-472
Number of pages6
JournalGynecologic Oncology
Volume65
Issue number3
DOIs
Publication statusPublished - Jun 1997

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Ovary
Lymph Nodes
Carcinoma
Survival
Residual Neoplasm
Lymph Node Excision
Ovarian Neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Carnino, F., Fuda, G., Ciccone, G., Iskra, L., Guercio, E., Dadone, D., & Conte, P. F. (1997). Significance of lymph node sampling in epithelial carcinoma of the ovary. Gynecologic Oncology, 65(3), 467-472. https://doi.org/10.1006/gyno.1997.4633

Significance of lymph node sampling in epithelial carcinoma of the ovary. / Carnino, Flavio; Fuda, Giancarlo; Ciccone, Giovannino; Iskra, Lilliana; Guercio, Elso; Dadone, Domenico; Conte, Pier Franco.

In: Gynecologic Oncology, Vol. 65, No. 3, 06.1997, p. 467-472.

Research output: Contribution to journalArticle

Carnino, F, Fuda, G, Ciccone, G, Iskra, L, Guercio, E, Dadone, D & Conte, PF 1997, 'Significance of lymph node sampling in epithelial carcinoma of the ovary', Gynecologic Oncology, vol. 65, no. 3, pp. 467-472. https://doi.org/10.1006/gyno.1997.4633
Carnino F, Fuda G, Ciccone G, Iskra L, Guercio E, Dadone D et al. Significance of lymph node sampling in epithelial carcinoma of the ovary. Gynecologic Oncology. 1997 Jun;65(3):467-472. https://doi.org/10.1006/gyno.1997.4633
Carnino, Flavio ; Fuda, Giancarlo ; Ciccone, Giovannino ; Iskra, Lilliana ; Guercio, Elso ; Dadone, Domenico ; Conte, Pier Franco. / Significance of lymph node sampling in epithelial carcinoma of the ovary. In: Gynecologic Oncology. 1997 ; Vol. 65, No. 3. pp. 467-472.
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