The authors evaluated CFU-GM growth in 35 patients with AnLL based on a comparison between the number of aggregates grown in cultures of marrow cells and the number of aggregates grown in cultures of peripheral blood cells. When the authors correlated this comparison with the clinical outcome of the disease, we found that patients entering complete remission (CR) showed a persistence of the effect of a marrow-blood barrier (MBB), whereas patients failing to enter CR demonstrated a failure of the effect of MBB. Patients in the group with persistence of MBB gave more marrow growths than peripheral blood growths or vice versa. The aim of their work is to focus attention on the meaning of CFU-GM growth in AnLL and the possible practical application of the evaluation of the biologic index of MBB so as to correlate it to clinical outcome in patients with AnLL.
|Number of pages||6|
|Publication status||Published - 1985|
ASJC Scopus subject areas