Significance of marrow-blood barrier for CFU-GM in patients with acute nonlymphoid leukemia (AnLL)

Research output: Contribution to journalArticle

Abstract

The authors evaluated CFU-GM growth in 35 patients with AnLL based on a comparison between the number of aggregates grown in cultures of marrow cells and the number of aggregates grown in cultures of peripheral blood cells. When the authors correlated this comparison with the clinical outcome of the disease, we found that patients entering complete remission (CR) showed a persistence of the effect of a marrow-blood barrier (MBB), whereas patients failing to enter CR demonstrated a failure of the effect of MBB. Patients in the group with persistence of MBB gave more marrow growths than peripheral blood growths or vice versa. The aim of their work is to focus attention on the meaning of CFU-GM growth in AnLL and the possible practical application of the evaluation of the biologic index of MBB so as to correlate it to clinical outcome in patients with AnLL.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalHaematologica
Volume70
Issue number4
Publication statusPublished - 1985

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Granulocyte-Macrophage Progenitor Cells
Leukemia
Bone Marrow
Growth
Blood Cells
Cell Count

ASJC Scopus subject areas

  • Hematology

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Significance of marrow-blood barrier for CFU-GM in patients with acute nonlymphoid leukemia (AnLL). / Ghizzi, A.; Stella, C. C.; Pedrazzoli, P.

In: Haematologica, Vol. 70, No. 4, 1985, p. 303-308.

Research output: Contribution to journalArticle

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