Abstract
The background of this article is as follows: Few data are available about the persistence of serum-specific IgG antibodies to L. infantum after acute VL. The objective of this article is to evaluate the persistence of antibodies against L. infantum in patients healed from acute VL, and the kinetic of the same antibodies observed in 2 cases of VL relapse and 2 cases of resistance to therapy. The methods which we used to obtain our objective are the following: 55 apparently immunocompetent, HIV-negative patients were examined for antibodies to L. infantum by IFAT over 14 years period, and we got the following results: Serum-specific IgG antibodies titers decrease slowly, but constantly. In the patients with a diagnosis of VL relapse, the kinetic of antibodies was characterized by an initial reduction, and a subsequent antibody levels rapidly increase, while in the patients with a clinical and parasitological diagnosis of VL not responding to specific therapy, we demonstrated persistent high level of antibodies to L. infantum. Finally, we conclude that specific antibodies to L. infantum might persist for many years, and decrease slowly, but steadily. The persistence of these specific antibodies is not related to poor therapeutic response or prognosis, but an acute increase in their levels might be a sentinel of a VL relapse, while persistence of high antibody levels could suggest a resistance to therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 127-132 |
| Number of pages | 6 |
| Journal | Clinical and Experimental Medicine |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 2012 |
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Keywords
- Kinetic of antibodies
- L. infantum
- Persistence of antibodies
- Visceral leishmaniasis
- VL relapse
- VL resistance
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Significance of persistence of antibodies against Leishmania infantum in sicilian patients affected by acute visceral leishmaniasis. / Mansueto, Pasquale; Pepe, Ilenia; Seidita, Aurelio; Scozzari, Francesca; Vitale, Giustina; Arcoleo, Francesco; Elvira, Inglese; Cillari, Enrico; Rini, Giovam Battista; Napoli, Nicola; Di Rosa, Salvatore; Mansueto, Serafino; Di Fede, Gaetana.
In: Clinical and Experimental Medicine, Vol. 12, No. 2, 06.2012, p. 127-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Significance of persistence of antibodies against Leishmania infantum in sicilian patients affected by acute visceral leishmaniasis
AU - Mansueto, Pasquale
AU - Pepe, Ilenia
AU - Seidita, Aurelio
AU - Scozzari, Francesca
AU - Vitale, Giustina
AU - Arcoleo, Francesco
AU - Elvira, Inglese
AU - Cillari, Enrico
AU - Rini, Giovam Battista
AU - Napoli, Nicola
AU - Di Rosa, Salvatore
AU - Mansueto, Serafino
AU - Di Fede, Gaetana
PY - 2012/6
Y1 - 2012/6
N2 - The background of this article is as follows: Few data are available about the persistence of serum-specific IgG antibodies to L. infantum after acute VL. The objective of this article is to evaluate the persistence of antibodies against L. infantum in patients healed from acute VL, and the kinetic of the same antibodies observed in 2 cases of VL relapse and 2 cases of resistance to therapy. The methods which we used to obtain our objective are the following: 55 apparently immunocompetent, HIV-negative patients were examined for antibodies to L. infantum by IFAT over 14 years period, and we got the following results: Serum-specific IgG antibodies titers decrease slowly, but constantly. In the patients with a diagnosis of VL relapse, the kinetic of antibodies was characterized by an initial reduction, and a subsequent antibody levels rapidly increase, while in the patients with a clinical and parasitological diagnosis of VL not responding to specific therapy, we demonstrated persistent high level of antibodies to L. infantum. Finally, we conclude that specific antibodies to L. infantum might persist for many years, and decrease slowly, but steadily. The persistence of these specific antibodies is not related to poor therapeutic response or prognosis, but an acute increase in their levels might be a sentinel of a VL relapse, while persistence of high antibody levels could suggest a resistance to therapy.
AB - The background of this article is as follows: Few data are available about the persistence of serum-specific IgG antibodies to L. infantum after acute VL. The objective of this article is to evaluate the persistence of antibodies against L. infantum in patients healed from acute VL, and the kinetic of the same antibodies observed in 2 cases of VL relapse and 2 cases of resistance to therapy. The methods which we used to obtain our objective are the following: 55 apparently immunocompetent, HIV-negative patients were examined for antibodies to L. infantum by IFAT over 14 years period, and we got the following results: Serum-specific IgG antibodies titers decrease slowly, but constantly. In the patients with a diagnosis of VL relapse, the kinetic of antibodies was characterized by an initial reduction, and a subsequent antibody levels rapidly increase, while in the patients with a clinical and parasitological diagnosis of VL not responding to specific therapy, we demonstrated persistent high level of antibodies to L. infantum. Finally, we conclude that specific antibodies to L. infantum might persist for many years, and decrease slowly, but steadily. The persistence of these specific antibodies is not related to poor therapeutic response or prognosis, but an acute increase in their levels might be a sentinel of a VL relapse, while persistence of high antibody levels could suggest a resistance to therapy.
KW - Kinetic of antibodies
KW - L. infantum
KW - Persistence of antibodies
KW - Visceral leishmaniasis
KW - VL relapse
KW - VL resistance
UR - http://www.scopus.com/inward/record.url?scp=84861481799&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861481799&partnerID=8YFLogxK
U2 - 10.1007/s10238-011-0150-9
DO - 10.1007/s10238-011-0150-9
M3 - Article
VL - 12
SP - 127
EP - 132
JO - Zeitschrift für Die Gesamte Experimentelle Medizin
JF - Zeitschrift für Die Gesamte Experimentelle Medizin
SN - 1591-8890
IS - 2
ER -