Significance of platelet and AFP levels and liver function parameters for HCC size and survival

Brian I. Carr, Vito Guerra, Edoardo G. Giannini, Fabio Farinati, Francesca Ciccarese, Gian Ludovico Rapaccini, Maria Di Marco, Luisa Benvegnù, Marco Zoli, Franco Borzio, Eugenio Caturelli, Maria Chiaramonte, Franco Trevisani

Research output: Contribution to journalArticle

Abstract

Methods: Prospectively-collected HCC patients’ data from a large Italian database were arranged according to the maximum tumor diameter (MTD) and divided into tumor size terciles, which were then compared in terms of several common clinical parameters and patients’ survival.

Background: Hepatocellular carcinoma (HCC) is a heterogeneous disease with both tumor and liver factors being involved. Aims: To investigate HCC clinical phenotypes and factors related to HCC size.

Results: An higer MTD tercile was significantly associated with increased blood alpha-fetoprotein (AFP), gamma-glutamyl transpeptidase (GGTP), and platelet levels. Patients with higher platelet levels had larger tumors and higher GGTP levels, with lower bilirubin levels. However, patients with the highest AFP levels had larger tumors and higher bilirubin levels, reflecting an aggressive biology. AFP correlation analysis revealed the existence of 2 different groups of patients: those with higher and with lower AFP levels, each with different patient and tumor characteristics. The Cox proportional-hazard model showed that a higher risk of death was correlated with GGTP and bilirubin levels, tumor size and number, and portal vein thrombosis (PVT), but not with AFP or platelet levels.

Conclusions: An increased tumor size was associated with increased blood platelet counts, AFP and GGTP levels. Platelet and AFP levels were important indicators of tumor size, but not of survival.

Original languageEnglish
Pages (from-to)e215-e223
JournalInternational Journal of Biological Markers
Volume29
Issue number3
DOIs
Publication statusPublished - Jul 1 2014

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alpha-Fetoproteins
Platelets
Liver
Tumors
Hepatocellular Carcinoma
Blood Platelets
Survival
gamma-Glutamyltransferase
Neoplasms
Bilirubin
Blood
Portal Vein
Platelet Count
Proportional Hazards Models
Hazards
Thrombosis
Databases
Phenotype

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Significance of platelet and AFP levels and liver function parameters for HCC size and survival. / Carr, Brian I.; Guerra, Vito; Giannini, Edoardo G.; Farinati, Fabio; Ciccarese, Francesca; Rapaccini, Gian Ludovico; Di Marco, Maria; Benvegnù, Luisa; Zoli, Marco; Borzio, Franco; Caturelli, Eugenio; Chiaramonte, Maria; Trevisani, Franco.

In: International Journal of Biological Markers, Vol. 29, No. 3, 01.07.2014, p. e215-e223.

Research output: Contribution to journalArticle

Carr, BI, Guerra, V, Giannini, EG, Farinati, F, Ciccarese, F, Rapaccini, GL, Di Marco, M, Benvegnù, L, Zoli, M, Borzio, F, Caturelli, E, Chiaramonte, M & Trevisani, F 2014, 'Significance of platelet and AFP levels and liver function parameters for HCC size and survival', International Journal of Biological Markers, vol. 29, no. 3, pp. e215-e223. https://doi.org/10.5301/jbm.5000064
Carr, Brian I. ; Guerra, Vito ; Giannini, Edoardo G. ; Farinati, Fabio ; Ciccarese, Francesca ; Rapaccini, Gian Ludovico ; Di Marco, Maria ; Benvegnù, Luisa ; Zoli, Marco ; Borzio, Franco ; Caturelli, Eugenio ; Chiaramonte, Maria ; Trevisani, Franco. / Significance of platelet and AFP levels and liver function parameters for HCC size and survival. In: International Journal of Biological Markers. 2014 ; Vol. 29, No. 3. pp. e215-e223.
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AU - Ciccarese, Francesca

AU - Rapaccini, Gian Ludovico

AU - Di Marco, Maria

AU - Benvegnù, Luisa

AU - Zoli, Marco

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