Significant reduction in HIV-1 plasma virl load but not in proviral infected cells during sub-optimal antiretroviral therapy

E. Riva, G. Antonelli, M. C. Solmone, O. Turriziani, P. Narciso, V. Tozzi, F. Dianzani

Research output: Contribution to journalArticle

Abstract

Attempts to eradicate HIV infection through highly active antiretroviral therapy (HAART) in the very early stages of the infection have failed due to the resumption of viral replication from unknown reservoirs. It has been postulated that antiretroviral therapy capable of suppressing viral replication, as shown by reduction of HIV-RNA copies in plasma and lymph nodes, should have less effect on the number of HIV-DNA carrying cells in the same districts. To test this hypothesis, plasma viremia and the proportion of provirally infected cells in peripheral blood and in lymph nodes were measured in patients at 3 and 6 months of treatment with zidovudine plus lamivudine. All patients showed a significant decrease in plasma viremia at 3 months that was maintained at 6 months (mean values of 1.6 ± 0.6 log10 from baseline). Conversely the proportion of HIV-DNA carrying cells slightly declined at 3 months but remained substantially stable thereafter both in peripheral blood and in lymph nodes. Taken together these data suggest that this therapeutic regimen, although sub-optimal, is effective in significantly reducing the virus production by productively infected cells but does not seem to substantially affect the load of provirally infected cells.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalJournal of Biological Regulators and Homeostatic Agents
Volume14
Issue number1
Publication statusPublished - 2000

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Keywords

  • Combination therapy
  • Provirally infected cells
  • Viral load

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)

Cite this

Riva, E., Antonelli, G., Solmone, M. C., Turriziani, O., Narciso, P., Tozzi, V., & Dianzani, F. (2000). Significant reduction in HIV-1 plasma virl load but not in proviral infected cells during sub-optimal antiretroviral therapy. Journal of Biological Regulators and Homeostatic Agents, 14(1), 1-3.