Significant (re)location: How to use chromatin and/or abundant proteins as messages of life and death

Research output: Contribution to journalArticlepeer-review

Abstract

Chromatin proteins package the genome and modulate its accessibility for transcription and all other transactions. However, recent work reveals that the chromatin proteins histone H1 and high-mobility group box protein 1 can also be used as signals during cell apoptosis and necrosis, respectively. Is there a reason why dying cells should use their own chromatin to signal that they are going to die or how they have died? This article will argue that any protein in a segregated compartment can be useful for signalling purposes when it leaves its usual location. Might actins, tubulins, lamins and DNA itself have signalling roles?

Original languageEnglish
Pages (from-to)287-293
Number of pages7
JournalTrends in Cell Biology
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 2004

ASJC Scopus subject areas

  • Cell Biology

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