TY - JOUR
T1 - Significant (re)location
T2 - How to use chromatin and/or abundant proteins as messages of life and death
AU - Bianchi, Marco E.
PY - 2004/6
Y1 - 2004/6
N2 - Chromatin proteins package the genome and modulate its accessibility for transcription and all other transactions. However, recent work reveals that the chromatin proteins histone H1 and high-mobility group box protein 1 can also be used as signals during cell apoptosis and necrosis, respectively. Is there a reason why dying cells should use their own chromatin to signal that they are going to die or how they have died? This article will argue that any protein in a segregated compartment can be useful for signalling purposes when it leaves its usual location. Might actins, tubulins, lamins and DNA itself have signalling roles?
AB - Chromatin proteins package the genome and modulate its accessibility for transcription and all other transactions. However, recent work reveals that the chromatin proteins histone H1 and high-mobility group box protein 1 can also be used as signals during cell apoptosis and necrosis, respectively. Is there a reason why dying cells should use their own chromatin to signal that they are going to die or how they have died? This article will argue that any protein in a segregated compartment can be useful for signalling purposes when it leaves its usual location. Might actins, tubulins, lamins and DNA itself have signalling roles?
UR - http://www.scopus.com/inward/record.url?scp=2942735137&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2942735137&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2004.04.004
DO - 10.1016/j.tcb.2004.04.004
M3 - Article
C2 - 15183185
AN - SCOPUS:2942735137
VL - 14
SP - 287
EP - 293
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 6
ER -