Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents: A randomized controlled trial

Thomas G. Pickering, Alexander M M Shepherd, Ian Puddey, Dale B. Glasser, John Orazem, Nancy Sherman, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

Erectile dysfunction (ED) is common among men taking antihypertensive drugs to control blood pressure. We evaluated the safety and efficacy of sildenafil citrate for treating ED in men taking multiple antihypertensive medications in a randomized, double-blind, placebo-controlled trial. A total of 568 men (80% of all patients (regardless of initial treatment group) had improved erections and intercourse. During double-blind treatment, 40% of sildenafil-treated and 25% of placebo-treated patients experienced adverse events; fewer than 2% in each group discontinued because of adverse events. Sildenafil was an effective and well tolerated treatment for ED in men receiving multiple antihypertensives. The results suggest that there were no additional safety risks associated with the use of sildenafil in these patients.

Original languageEnglish
Pages (from-to)1135-1142
Number of pages8
JournalAmerican Journal of Hypertension
Volume17
Issue number12
DOIs
Publication statusPublished - Dec 2004

Keywords

  • antihypertensive agents
  • drug safety
  • hypertension
  • Impotence
  • phosphodiesterase inhibitor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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