Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study

M. Diomedi; F. Sallustio; B. Rizzato; F. Ferrante; G. Leone; E. Spera; M. Scarfini; G. Bernardi

doi:10.1212/01.wnl.0000173835.12308.bb

Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study

M. Diomedi, F. Sallustio, B. Rizzato, F. Ferrante, G. Leone, E. Spera, M. Scarfini, G. Bernardi

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.

Original language	English
Pages (from-to)	919-921
Number of pages	3
Journal	Neurology
Volume	65
Issue number	6
DOIs	https://doi.org/10.1212/01.wnl.0000173835.12308.bb
Publication status	Published - Sep 27 2005

ASJC Scopus subject areas

Neuroscience(all)

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AU - Diomedi, M.

AU - Sallustio, F.

AU - Rizzato, B.

AU - Ferrante, F.

AU - Leone, G.

AU - Spera, E.

AU - Scarfini, M.

AU - Bernardi, G.

PY - 2005/9/27

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AB - The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.

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Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study

Abstract

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