Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study

M. Diomedi, F. Sallustio, B. Rizzato, F. Ferrante, G. Leone, E. Spera, M. Scarfini, G. Bernardi

Research output: Contribution to journalArticlepeer-review


The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.

Original languageEnglish
Pages (from-to)919-921
Number of pages3
Issue number6
Publication statusPublished - Sep 27 2005

ASJC Scopus subject areas

  • Neuroscience(all)


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