Silent chemoattractant receptors: D6 as a decoy and scavenger receptor for inflammatory CC chemokines

Massimo Locati, Yeny Martinez De La Torre, Emanuela Galliera, Raffaella Bonecchi, Haribabu Bodduluri, Gianluca Vago, Annunciata Vecchi, Alberto Mantovani

Research output: Contribution to journalArticle

Abstract

The chemokine system includes at least three "silent" receptors, DARC, D6 and CCX CKR, with distinct specificity and tissue distribution. D6 binds most inflammatory, but not homeostatic, CC chemokines and shuttles in a ligand-independent way from the plasma membrane to endocytic compartments where chemokines are targeted to degradation. In vitro and in vivo evidence, including results with gene-targeted mice, is consistent with the view that D6 acts as a decoy and scavenger for inflammatory CC chemokines. Thus, D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium to dampen inflammation in tissues and draining lymph nodes.

Original languageEnglish
Pages (from-to)679-686
Number of pages8
JournalCytokine and Growth Factor Reviews
Volume16
Issue number6
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Chemokine receptors
  • Chemokines
  • D6
  • Decoy receptors
  • Inflammation

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

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