Silent myocardial ischemia and late ventricular repolarization in the genesis of ventricular fibrillation in humans

Vincenzo Santinelli, Pasqualina Modano, Maria Ferraiuolo, Daniela De Santo, Igino Oppo, Pasquale Fornaro, Massimo Chiariello

Research output: Contribution to journalArticle

Abstract

Background: We report a well-documented case of a patient, a 62-year- old man, with severe and asymptomatic left main coronary artery disease who had several episodes of silent myocardial ischemia and a syncopal attack during Holter recording. Methods and Results: Ambulatory monitoring showed isolated giant U waves separated from the T wave 60 minutes before syncope that was due to reversible ventricular fibrillation lasting about 4 minutes and spontaneously reverting to asystole (7 seconds) and then to atrial fibrillation. Conclusion: Our experience suggests that myocardial ischemia may differently affect the repolarization times within the myocardium leading to widely disparate repolarization gradients that may represent the arrhythmogenic substrate for the occurrence of life-threatening ventricular tachyarrhythmias.

Original languageEnglish
Pages (from-to)250-254
Number of pages5
JournalAnnals of Noninvasive Electrocardiology
Volume4
Issue number2
DOIs
Publication statusPublished - 1999

Keywords

  • Myocardial ischemia
  • Repolarization
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Silent myocardial ischemia and late ventricular repolarization in the genesis of ventricular fibrillation in humans'. Together they form a unique fingerprint.

Cite this