Occupational exposure to crystalline silica dust rapresented in the last century one of the most important dispose of enviromental medicine mainly for lung involvement. Thechnological advances have contributed to substantially reducing the occurrence of silicosis and other respiratory disorders by decreasing the exposure levels to silica dust. Actually there is increasing evidence from epidemiologic studies that silica dust exposure is associated with increased risk for a wide variety of autoimmune diseases, including scleroderma, rheumatoid artritis, systemic sclerosis, systemic lupus erythematosus, vasculitis and impared renal function and end-stage renal diseases. Mechanisms of autoimmune induction following exposure to particulate silica are unclear, although an adjuvant effect is proposed. Silica dust may act to promote or accelerate disease development, requiring some other factor to break immune tolerance or initiate autoimmunity. It has been hypotizied that crystalline silica could promote both the activation of inflammatory pathway, that the production of autoantibodies through abnormal regulation of apoptosis. The specific manifestation of this effect may depend on underlying differences in genetic susceptibility or other environmental exposures. However more affords are needed to clarified the pathogenesis of autoimmunity. We report three clinical case in which crystalline silica dust exposure could has promoted development of autoimmune disease.
|Translated title of the contribution||Silica and immunologic disorders: Possible prospective in occupational medicine|
|Number of pages||2|
|Journal||Giornale Italiano di Medicina del Lavoro ed Ergonomia|
|Issue number||3 SUPPL.|
|Publication status||Published - Jul 2006|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health