Abstract
Lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH) are associated with erectile dysfunction. Alpha-1-adrenoceptor antagonists are effective drugs for treating symptomatic BPH. Clinical data show improvements in LUTS by phosphodiesterase 5 inhibitors. This study aimed to evaluate effects of silodosin, a highly selective α1A-adrenoceptor antagonist, alone or in combination with the phosphodiesterase 5 inhibitor tadalafil on contractions of isolated human and rat prostates. In organbath studies, effects of increasing concentrations of silodosin (1 nM-1 μM) and tadalafil (100 nM-100 μM) on contractions by electrical field stimulation or phenylephrine of human and rat prostate strip preparations were investigated. The combination silodosin and tadalafil reduced electrically-induced contractions of human prostate preparations better than single drugs alone. At any frequencies (1-32 Hz), inhibitory effects of combined therapy (P-values vs single drug) in human tissue were 26-42% (1 nM silodosin+100 nM tadalafil; P1A-adrenoceptor antagonist and a phosphodiesterase 5 inhibitor for symptomatic BPH and suggests that the drug combination requires endogenous nerve-activity for optimal effect.
Original language | English |
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Pages (from-to) | 42-51 |
Number of pages | 10 |
Journal | European Journal of Pharmacology |
Volume | 744 |
DOIs | |
Publication status | Published - Dec 5 2014 |
Keywords
- Alfa-1A-adrenoceptor
- Contraction
- Inhibition
- Phosphodiesterase 5
- Prostate
- Smooth muscle
ASJC Scopus subject areas
- Pharmacology
- Medicine(all)