SIM 6080, A New Calcium Antagonist, Reduces Aortic Atherosclerosis in Cholesterol-Fed Rabbits

F. M. Maggi, F. Bernini, L. Barberi, M. Fantoni, A. L. Catapano

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

SIM 6080 is a new calcium antagonist, structurally related to diphenylalkylamines, which combines transmembrane and intracellular calcium antagonist activities. In the present study we investigated the effect of SIM 6080 on atherogenesis in cholesterol-fed rabbits. Subcutaneous administration of the compound at 0.33, 1, and 3 mg kg-1/bid for 60 days neither affected plasma lipids nor blood pressure. However at 1 and 3 mg kg-1/bid SIM 6080 reduced in a dosedependent manner both the area of the aorta covered by plaques and aortic cholesterol content. Determination of SIM 6080 plasma and aortic content indicated that the compound could concentrate up to 10 times in the arterial tissue. In vitro studies demonstrated that at concentrations similar to those observed in the aorta this compound may stimulate rabbit βVLDL catabolism by smooth muscle cells in an homologous system suggesting that the up-regulation of LDL-receptors in the aorta may contribute to the antiatherosclerotic properties of SIM 6080.

Original languageEnglish
Pages (from-to)219-228
Number of pages10
JournalPharmacological Research
Volume28
Issue number3
DOIs
Publication statusPublished - Oct 1993

Fingerprint

Atherosclerosis
Cholesterol
Rabbits
Calcium
Aorta
LDL Receptors
Smooth Muscle Myocytes
Up-Regulation
SIM 6080
Blood Pressure
Lipids

Keywords

  • Lipoproteins, β VLDL, smooth muscle cells

ASJC Scopus subject areas

  • Pharmacology

Cite this

SIM 6080, A New Calcium Antagonist, Reduces Aortic Atherosclerosis in Cholesterol-Fed Rabbits. / Maggi, F. M.; Bernini, F.; Barberi, L.; Fantoni, M.; Catapano, A. L.

In: Pharmacological Research, Vol. 28, No. 3, 10.1993, p. 219-228.

Research output: Contribution to journalArticle

Maggi, F. M. ; Bernini, F. ; Barberi, L. ; Fantoni, M. ; Catapano, A. L. / SIM 6080, A New Calcium Antagonist, Reduces Aortic Atherosclerosis in Cholesterol-Fed Rabbits. In: Pharmacological Research. 1993 ; Vol. 28, No. 3. pp. 219-228.
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