Similar binding to glutamate receptors by Rasmussen and partial epilepsy patients' sera

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Abstract

Immunoreactivity of sera from patients with Rasmussen encephalitis (RE) and patients with partial epilepsy (PE) was analyzed by immunohistoblot on rat brain sections and the staining pattern compared with that obtained with antibodies to a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and NMDA receptors. Staining for anti-glutamate receptor 3 (GluR3) was found in 82% of patients with RE and 64% of patients with PE. Histoblot analysis showed a positive staining in GluR3- and NMDA-specific regions of rat brain, providing a comprehensive CNS immunolocalization.

Original languageEnglish
Pages (from-to)1998-2001
Number of pages4
JournalNeurology
Volume59
Issue number12
Publication statusPublished - Dec 24 2002

ASJC Scopus subject areas

  • Neuroscience(all)

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