Similar effects of nifedipine and hydralazine on anaesthesia and hypermotility induced by pentobarbitone in mice

M. Sansone, F. Pavone, M. Battaglia, W. Daniel, J. Vetulani

Research output: Contribution to journalArticle

Abstract

Nifedipine, a dihydropyridine calcium channel blocker, and hydralazine, a non-calcium channel antagonist vasodilatator enhanced pentobarbitone-induced sleeping time and reversed locomotor hyperactivity induced by a subhypnotic dose of the barbiturate in mice. The similarity of the behavioural effects, exerted by nifedipine and hydralazine, suggest that haemodynamic factors may play an important role in the interaction of calcium channel antagonists with barbiturates.

Original languageEnglish
Pages (from-to)453-455
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume44
Issue number5
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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