Experimental and clinical data suggest a basal ganglia involvement in different types of refractory epilepsy. The aim of this study is to determine if SPET study reveals differences between patients affected by ring chromosome 20 syndrome [(R(20)] and patients with drug-resistant temporal lobe epilepsy [TLE] in presynaptic termination of dopaminergic nigro-striatal neurons and postsynaptic dopamine receptors, administrating 123I-ioflupane and 123I-IBZM. Patients with R(20) and TLE showed a similar pattern of postsynaptic dopaminergic dysfunction. Regarding the presynaptic termination of dopaminergic nigro-striatal neurons, we found a wide heterogeneity in R(20) group, probably related to large clinical differences. Interestingly, patients with a lower seizure frequency showed a higher dopaminergic activity, and an inverse correlation between mosaicism percentage and dopaminergic nigro-striatal neurons occurred.
|Translated title of the contribution||Similar pattern of dopaminergic dysfunction in patients with ring chromosome 20 epilepsy and temporal lobe epilepsy: Pre- and post-synaptic evaluation by SPET|
|Number of pages||4|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - Apr 2010|
ASJC Scopus subject areas
- Clinical Neurology