Disfunzione dopaminergica con caratteristiche simili in pazienti con sindrome del cromosoma 20 ad anello ed epilessia temporale: Studio pree post-sinaptico mediante SPECT

Translated title of the contribution: Similar pattern of dopaminergic dysfunction in patients with ring chromosome 20 epilepsy and temporal lobe epilepsy: Pre- and post-synaptic evaluation by SPET

V. Chiesa, A. Del Sole, G. Lucignani, L. Giordano, F. La Briola, A. Vignoli, F. Elisei, L. Gilardi, R. Canger, M. P. Canevini

Research output: Contribution to journalArticle

Abstract

Experimental and clinical data suggest a basal ganglia involvement in different types of refractory epilepsy. The aim of this study is to determine if SPET study reveals differences between patients affected by ring chromosome 20 syndrome [(R(20)] and patients with drug-resistant temporal lobe epilepsy [TLE] in presynaptic termination of dopaminergic nigro-striatal neurons and postsynaptic dopamine receptors, administrating 123I-ioflupane and 123I-IBZM. Patients with R(20) and TLE showed a similar pattern of postsynaptic dopaminergic dysfunction. Regarding the presynaptic termination of dopaminergic nigro-striatal neurons, we found a wide heterogeneity in R(20) group, probably related to large clinical differences. Interestingly, patients with a lower seizure frequency showed a higher dopaminergic activity, and an inverse correlation between mosaicism percentage and dopaminergic nigro-striatal neurons occurred.

Translated title of the contributionSimilar pattern of dopaminergic dysfunction in patients with ring chromosome 20 epilepsy and temporal lobe epilepsy: Pre- and post-synaptic evaluation by SPET
Original languageItalian
Pages (from-to)226-229
Number of pages4
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number140
Publication statusPublished - Apr 2010

ASJC Scopus subject areas

  • Clinical Neurology

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    Chiesa, V., Del Sole, A., Lucignani, G., Giordano, L., La Briola, F., Vignoli, A., Elisei, F., Gilardi, L., Canger, R., & Canevini, M. P. (2010). Disfunzione dopaminergica con caratteristiche simili in pazienti con sindrome del cromosoma 20 ad anello ed epilessia temporale: Studio pree post-sinaptico mediante SPECT. Bollettino - Lega Italiana contro l'Epilessia, (140), 226-229.