Similarities and Differences in Allocation Policies for Pediatric Liver Transplantation Across the World

Björn Fischler, Ulrich Baumann, Daniel D'Agostino, Lorenzo D'Antiga, Antal Dezsofi, Dominique Debray, Ozlem Durmaz, Helen Evans, Esteban Frauca, Nedim Hadzic, Jörg Jahnel, Jerome Loveland, Valérie McLin, Vicky Lee Ng, Valerio Nobili, Joanna Pawłowska, Khalid Sharif, Francoise Smets, Henkjan J Verkade, Evelyn HsuSimon Horslen, John Bucuvalas

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: We aimed to investigate national allocation policies for pediatric liver transplantation.

METHOD: A survey was prepared by the ESPGHAN hepatology committee in collaboration with the North-American SPLIT (Studies of Pediatric Liver Transplantation) consortium. The survey was sent to pediatric hepatologists and transplant surgeons worldwide. National data were obtained from centrally based registries.

RESULTS: Replies were obtained from 15 countries from five of the world continents. Overall donation rate varied between 9 and 35 per million inhabitants. The number of pediatric liver transplantations was 4-9 per million inhabitants below 18 years of age for 13 of the 15 respondents. In children below 2 years of age mortality on the waiting list varied between 0 and 20%. In the same age group, there were large differences in the ratio of living donor liver transplantation to deceased donor liver transplantation as well as in the ratio of split liver segments to whole liver. These differences were associated with possible discrepancies in waiting list mortality.

CONCLUSION: Similarities but also differences between countries were detected. The described data may be of importance when trying to reduce waiting list mortality in the youngest children.

Original languageEnglish
JournalJournal of Pediatric Gastroenterology and Nutrition
DOIs
Publication statusE-pub ahead of print - Jan 21 2019

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Liver Transplantation
Waiting Lists
Pediatrics
Mortality
Living Donors
Liver
Gastroenterology
Registries
Age Groups
Tissue Donors
Transplants
Surveys and Questionnaires

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Similarities and Differences in Allocation Policies for Pediatric Liver Transplantation Across the World. / Fischler, Björn; Baumann, Ulrich; D'Agostino, Daniel; D'Antiga, Lorenzo; Dezsofi, Antal; Debray, Dominique; Durmaz, Ozlem; Evans, Helen; Frauca, Esteban; Hadzic, Nedim; Jahnel, Jörg; Loveland, Jerome; McLin, Valérie; Ng, Vicky Lee; Nobili, Valerio; Pawłowska, Joanna; Sharif, Khalid; Smets, Francoise; Verkade, Henkjan J; Hsu, Evelyn; Horslen, Simon; Bucuvalas, John.

In: Journal of Pediatric Gastroenterology and Nutrition, 21.01.2019.

Research output: Contribution to journalArticle

Fischler, B, Baumann, U, D'Agostino, D, D'Antiga, L, Dezsofi, A, Debray, D, Durmaz, O, Evans, H, Frauca, E, Hadzic, N, Jahnel, J, Loveland, J, McLin, V, Ng, VL, Nobili, V, Pawłowska, J, Sharif, K, Smets, F, Verkade, HJ, Hsu, E, Horslen, S & Bucuvalas, J 2019, 'Similarities and Differences in Allocation Policies for Pediatric Liver Transplantation Across the World', Journal of Pediatric Gastroenterology and Nutrition. https://doi.org/10.1097/MPG.0000000000002283
Fischler, Björn ; Baumann, Ulrich ; D'Agostino, Daniel ; D'Antiga, Lorenzo ; Dezsofi, Antal ; Debray, Dominique ; Durmaz, Ozlem ; Evans, Helen ; Frauca, Esteban ; Hadzic, Nedim ; Jahnel, Jörg ; Loveland, Jerome ; McLin, Valérie ; Ng, Vicky Lee ; Nobili, Valerio ; Pawłowska, Joanna ; Sharif, Khalid ; Smets, Francoise ; Verkade, Henkjan J ; Hsu, Evelyn ; Horslen, Simon ; Bucuvalas, John. / Similarities and Differences in Allocation Policies for Pediatric Liver Transplantation Across the World. In: Journal of Pediatric Gastroenterology and Nutrition. 2019.
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abstract = "OBJECTIVES: We aimed to investigate national allocation policies for pediatric liver transplantation.METHOD: A survey was prepared by the ESPGHAN hepatology committee in collaboration with the North-American SPLIT (Studies of Pediatric Liver Transplantation) consortium. The survey was sent to pediatric hepatologists and transplant surgeons worldwide. National data were obtained from centrally based registries.RESULTS: Replies were obtained from 15 countries from five of the world continents. Overall donation rate varied between 9 and 35 per million inhabitants. The number of pediatric liver transplantations was 4-9 per million inhabitants below 18 years of age for 13 of the 15 respondents. In children below 2 years of age mortality on the waiting list varied between 0 and 20{\%}. In the same age group, there were large differences in the ratio of living donor liver transplantation to deceased donor liver transplantation as well as in the ratio of split liver segments to whole liver. These differences were associated with possible discrepancies in waiting list mortality.CONCLUSION: Similarities but also differences between countries were detected. The described data may be of importance when trying to reduce waiting list mortality in the youngest children.",
author = "Bj{\"o}rn Fischler and Ulrich Baumann and Daniel D'Agostino and Lorenzo D'Antiga and Antal Dezsofi and Dominique Debray and Ozlem Durmaz and Helen Evans and Esteban Frauca and Nedim Hadzic and J{\"o}rg Jahnel and Jerome Loveland and Val{\'e}rie McLin and Ng, {Vicky Lee} and Valerio Nobili and Joanna Pawłowska and Khalid Sharif and Francoise Smets and Verkade, {Henkjan J} and Evelyn Hsu and Simon Horslen and John Bucuvalas",
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AU - Fischler, Björn

AU - Baumann, Ulrich

AU - D'Agostino, Daniel

AU - D'Antiga, Lorenzo

AU - Dezsofi, Antal

AU - Debray, Dominique

AU - Durmaz, Ozlem

AU - Evans, Helen

AU - Frauca, Esteban

AU - Hadzic, Nedim

AU - Jahnel, Jörg

AU - Loveland, Jerome

AU - McLin, Valérie

AU - Ng, Vicky Lee

AU - Nobili, Valerio

AU - Pawłowska, Joanna

AU - Sharif, Khalid

AU - Smets, Francoise

AU - Verkade, Henkjan J

AU - Hsu, Evelyn

AU - Horslen, Simon

AU - Bucuvalas, John

PY - 2019/1/21

Y1 - 2019/1/21

N2 - OBJECTIVES: We aimed to investigate national allocation policies for pediatric liver transplantation.METHOD: A survey was prepared by the ESPGHAN hepatology committee in collaboration with the North-American SPLIT (Studies of Pediatric Liver Transplantation) consortium. The survey was sent to pediatric hepatologists and transplant surgeons worldwide. National data were obtained from centrally based registries.RESULTS: Replies were obtained from 15 countries from five of the world continents. Overall donation rate varied between 9 and 35 per million inhabitants. The number of pediatric liver transplantations was 4-9 per million inhabitants below 18 years of age for 13 of the 15 respondents. In children below 2 years of age mortality on the waiting list varied between 0 and 20%. In the same age group, there were large differences in the ratio of living donor liver transplantation to deceased donor liver transplantation as well as in the ratio of split liver segments to whole liver. These differences were associated with possible discrepancies in waiting list mortality.CONCLUSION: Similarities but also differences between countries were detected. The described data may be of importance when trying to reduce waiting list mortality in the youngest children.

AB - OBJECTIVES: We aimed to investigate national allocation policies for pediatric liver transplantation.METHOD: A survey was prepared by the ESPGHAN hepatology committee in collaboration with the North-American SPLIT (Studies of Pediatric Liver Transplantation) consortium. The survey was sent to pediatric hepatologists and transplant surgeons worldwide. National data were obtained from centrally based registries.RESULTS: Replies were obtained from 15 countries from five of the world continents. Overall donation rate varied between 9 and 35 per million inhabitants. The number of pediatric liver transplantations was 4-9 per million inhabitants below 18 years of age for 13 of the 15 respondents. In children below 2 years of age mortality on the waiting list varied between 0 and 20%. In the same age group, there were large differences in the ratio of living donor liver transplantation to deceased donor liver transplantation as well as in the ratio of split liver segments to whole liver. These differences were associated with possible discrepancies in waiting list mortality.CONCLUSION: Similarities but also differences between countries were detected. The described data may be of importance when trying to reduce waiting list mortality in the youngest children.

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