Simple automated preparation of O-[11C]methyl-L-tyrosine for routine clinical use

Yoichi Ishikawa, Ren Iwata, Shozo Furumoto, Claudio Pascali, Anna Bogni, Kazuo Kubota, Kiichi Ishiwata

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The previously reported preparation of O-[11C]methyl-L-tyrosine ([11C]MT), a promising tumor imaging agent, has been now considerably simplified and automated. Main changes were the use of [11C]methyl iodide ([11C]MeI) in the reaction with l-tyrosine disodium and the use of solid phase extraction on commercially available cartridges instead of HPLC for the final purification. An injectable saline solution of [ 11C]MT was obtained within 30 min after EOB with radiochemical yield of ca. 60% (decay-corrected, based on [11C]MeI). Radiochemical purity was over 97%. The automated preparation was carried out using a miniature module employing manifold valves.

Original languageEnglish
Pages (from-to)55-61
Number of pages7
JournalApplied Radiation and Isotopes
Volume63
Issue number1
DOIs
Publication statusPublished - Jul 2005

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tyrosine
cartridges
preparation
purification
iodides
solid phases
purity
tumors
modules
decay

Keywords

  • Amino acid transport
  • Automated synthesis
  • C-11
  • O-methyl-L-tyrosine
  • Tumor imaging

ASJC Scopus subject areas

  • Radiation

Cite this

Simple automated preparation of O-[11C]methyl-L-tyrosine for routine clinical use. / Ishikawa, Yoichi; Iwata, Ren; Furumoto, Shozo; Pascali, Claudio; Bogni, Anna; Kubota, Kazuo; Ishiwata, Kiichi.

In: Applied Radiation and Isotopes, Vol. 63, No. 1, 07.2005, p. 55-61.

Research output: Contribution to journalArticle

Ishikawa, Yoichi ; Iwata, Ren ; Furumoto, Shozo ; Pascali, Claudio ; Bogni, Anna ; Kubota, Kazuo ; Ishiwata, Kiichi. / Simple automated preparation of O-[11C]methyl-L-tyrosine for routine clinical use. In: Applied Radiation and Isotopes. 2005 ; Vol. 63, No. 1. pp. 55-61.
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