Simple sugars inhibit proliferation of human T lymphocytes in autologous and allogeneic mixed lymphocyte reactions

Federico Licastro, Mariella Chiricolo, Pierluigi Tabacchi, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

Several oligo- and monosaccharides were studied for their capacity to modulate lymphocyte proliferation in human allogeneic and autologous mixed lymphocyte reactions (MLR). A defined subset of sugars showed a marked inhibitory effect on lymphocyte proliferative response in the majority of the allogeneic MLR combinations studied. The inhibitory effect disappeared when sugars were added to allogeneic MLR 96 hr after the beginning of culture. These sugars also showed a significant inhibitory power on autologous MLR, performed by using T- and non-T-enriched lymphocytes from the same donor. The reported data suggest that carbohydrate determinants are involved in the proliferative response of human lymphocytes in both autologous and allogeneic MLR.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalCellular Immunology
Volume107
Issue number1
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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