Simplified chemical and radiochemical synthesis of 2-arachidonoyl-glycerol, an endogenous ligand of cannabinoid receptors

Antonella Cartoni, Andrea Margonelli, Giancarlo Angelini, Alessandro Finazzi-Agrò, Mauro Maccarrone

Research output: Contribution to journalArticlepeer-review

Abstract

Endocannabinoids have emerged as a new class of lipid mediators, with manifold roles in the central nervous system and in the periphery. Several studies have identified 2-arachidonoyl-glycerol (2-AG) as a major endogenous agonist of cannabinoid receptors. Here, the chemical synthesis of 2-AG is reported, along with the synthesis of its tritium-labeled derivative. These unlabeled and radiolabeled compounds are suitable tools for unravelling some metabolic routes and biological activities of 2-AG in various cells and tissues.

Original languageEnglish
Pages (from-to)2723-2726
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number13
DOIs
Publication statusPublished - Mar 22 2004

Keywords

  • 1-AG, 1-arachidonoyl-glycerol
  • 2-AG, 2-arachidonoyl-glycerol
  • 2-Arachidonoyl-glycerol (2-AG)
  • [H]2-AG, labeled 2-arachidonoyl-glycerol
  • [H]AA, labeled arachidonic acid
  • AA, arachidonic acid
  • AEA, N- arachidonoylethanolamine

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Fingerprint Dive into the research topics of 'Simplified chemical and radiochemical synthesis of 2-arachidonoyl-glycerol, an endogenous ligand of cannabinoid receptors'. Together they form a unique fingerprint.

Cite this