TY - JOUR
T1 - Simplified, noninvasive PET measurement of blood-brain barrier permeability
AU - Iannotti, Fausto
AU - Fieschi, Cesare
AU - Alfano, Bruno
AU - Picozzi, Piero
AU - Mansi, Luigi
AU - Pozzilli, Carlo
AU - Punzo, Assunta
AU - Vecchio, Giuseppe Del
AU - Lenzi, Gian Luigi
AU - Salvatore, Marco
AU - Conforti, Paolo
PY - 1987
Y1 - 1987
N2 - Blood-brain barrier (BBB) permeability to [68Ga]EDTA was measured by positron emission tomography (PET) in four normal volunteers and in 11 patients with brain tumors. A unidirectional transfer constant, Ki, was calculated applying multiple-time graphical analysis (MTGA). This method allows the detection of backflux from brain to blood and, by generalization, the measurement of the constant Kb (brain to blood). Furthermore, the need for an independent measurement of the intravascular tracer is obviated: MTGA itself provides an estimate of the cerebral plasma volume (Vp). In the four normal volunteers the A, was 3.0 ± 0.8 x 10-4 ml g-1 min-1 (mean ± SD) and the Vp 0.034 ± 0.007 ml g-1. A net increase in Ks up to a maximum of 121.0 x 10-4 ml g-1 min-1 (correspondent value of Kb = 0.025 min-1) as well as an increase of Vp was observed in malignant tumors. The input function was calculated using both the [“GaJEDTA concentration in sequential arterial blood samples and, noninvasively, the activity derived from the superior sagittal sinus image. The values of and Vp from these two calculations were in good agreement. The application of MTGA to PET permits the evaluation of passage of substances across the BBB without making assumptions about the compartments in which the tracer distributes.
AB - Blood-brain barrier (BBB) permeability to [68Ga]EDTA was measured by positron emission tomography (PET) in four normal volunteers and in 11 patients with brain tumors. A unidirectional transfer constant, Ki, was calculated applying multiple-time graphical analysis (MTGA). This method allows the detection of backflux from brain to blood and, by generalization, the measurement of the constant Kb (brain to blood). Furthermore, the need for an independent measurement of the intravascular tracer is obviated: MTGA itself provides an estimate of the cerebral plasma volume (Vp). In the four normal volunteers the A, was 3.0 ± 0.8 x 10-4 ml g-1 min-1 (mean ± SD) and the Vp 0.034 ± 0.007 ml g-1. A net increase in Ks up to a maximum of 121.0 x 10-4 ml g-1 min-1 (correspondent value of Kb = 0.025 min-1) as well as an increase of Vp was observed in malignant tumors. The input function was calculated using both the [“GaJEDTA concentration in sequential arterial blood samples and, noninvasively, the activity derived from the superior sagittal sinus image. The values of and Vp from these two calculations were in good agreement. The application of MTGA to PET permits the evaluation of passage of substances across the BBB without making assumptions about the compartments in which the tracer distributes.
KW - Blood
KW - Brain barrier
KW - Brain, neoplasms
KW - Contrast media
KW - Emission computed tomography
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M3 - Article
C2 - 3106433
AN - SCOPUS:0023189211
VL - 11
SP - 390
EP - 397
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
SN - 0363-8715
IS - 3
ER -