Simplified preparation and characterization of magnetic hydroxyapatite-based nanocomposites

Stefania Scialla, Barbara Palazzo, Amilcare Barca, Luigi Carbone, Angela Fiore, Anna Grazia Monteduro, Giuseppe Maruccio, Alessandro Sannino, Francesca Gervaso

Research output: Contribution to journalArticle

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Abstract

Authors aimed to provide a magnetic responsiveness to bone-mimicking nano-hydroxyapatite (n-HA). For this purpose, dextran-grafted iron oxide nanoarchitectures (DM) were synthesized by a green-friendly and scalable alkaline co-precipitation method at room temperature and used to functionalize n-HA crystals. Different amounts of DM hybrid structures were added into the nanocomposites (DM/n-HA 1:1, 2:1 and 3:1weight ratio) which were investigated through extensive physicochemical (XRD, ICP, TGA and Zeta-potential), microstructural (TEM and DLS), magnetic (VSM) and biological analyses (MTT proliferation assay). X-ray diffraction patterns have confirmed the n-HA formation in the presence of DM as a co-reagent. Furthermore, the addition of DM during the synthesis does not affect the primary crystallite domains of DM/n-HA nanocomposites. DM/n-HAs have shown a rising of the magnetic moment values by increasing DM content up to 2:1 ratio. However, the magnetic moment value recorded in the DM/n-HA 3:1 do not further increase showing a saturation behaviour. The cytocompatibility of the DM/n-HA was evaluated with respect to the MG63 osteoblast-like cell line. Proliferation assays revealed that viability, carried out in the absence of external magnetic field, was not affected by the amount of DM employed. Interestingly, assays also suggested that the DM/n-HA nanocomposites exhibit a possible shielding effect with respect to the anti-proliferative activity induced by the DM particles alone.

Original languageEnglish
Pages (from-to)1166-1174
Number of pages9
JournalMaterials Science and Engineering C
Volume76
DOIs
Publication statusPublished - Jul 1 2017

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Durapatite
Hydroxyapatite
Nanocomposites
nanocomposites
preparation
magnetic moments
osteoblasts
dextrans
hybrid structures
cultured cells
iron oxides
viability
Assays
bones
shielding
reagents
diffraction patterns
Magnetic moments
saturation
transmission electron microscopy

Keywords

  • Journal Article

Cite this

Scialla, S., Palazzo, B., Barca, A., Carbone, L., Fiore, A., Monteduro, A. G., ... Gervaso, F. (2017). Simplified preparation and characterization of magnetic hydroxyapatite-based nanocomposites. Materials Science and Engineering C, 76, 1166-1174. https://doi.org/10.1016/j.msec.2017.03.060

Simplified preparation and characterization of magnetic hydroxyapatite-based nanocomposites. / Scialla, Stefania; Palazzo, Barbara; Barca, Amilcare; Carbone, Luigi; Fiore, Angela; Monteduro, Anna Grazia; Maruccio, Giuseppe; Sannino, Alessandro; Gervaso, Francesca.

In: Materials Science and Engineering C, Vol. 76, 01.07.2017, p. 1166-1174.

Research output: Contribution to journalArticle

Scialla, S, Palazzo, B, Barca, A, Carbone, L, Fiore, A, Monteduro, AG, Maruccio, G, Sannino, A & Gervaso, F 2017, 'Simplified preparation and characterization of magnetic hydroxyapatite-based nanocomposites', Materials Science and Engineering C, vol. 76, pp. 1166-1174. https://doi.org/10.1016/j.msec.2017.03.060
Scialla, Stefania ; Palazzo, Barbara ; Barca, Amilcare ; Carbone, Luigi ; Fiore, Angela ; Monteduro, Anna Grazia ; Maruccio, Giuseppe ; Sannino, Alessandro ; Gervaso, Francesca. / Simplified preparation and characterization of magnetic hydroxyapatite-based nanocomposites. In: Materials Science and Engineering C. 2017 ; Vol. 76. pp. 1166-1174.
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AU - Fiore, Angela

AU - Monteduro, Anna Grazia

AU - Maruccio, Giuseppe

AU - Sannino, Alessandro

AU - Gervaso, Francesca

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