Simultaneous alpha-1-antitrypsin accumulation in liver and pancreas

Francesco Callea, Johan Fevery, Valeer J. Desmet

Research output: Contribution to journalArticlepeer-review


Inclusions positive for periodic acid-Schiff, resistant to diastase, and immunoreactive to alpha-1-antitrypsin (AAT) were found in hepatocytes and pancreatic islet cells of a patient with clinical and pathologic features of AAT deficiency. Alpha-1-antitrypsin was detected in all pancreatic islets, and AAT-positive cells were observed in the excretory pancreatic ducts. These findings suggest that the pancreas synthesizes AAT and possibly serves as a "storage" place in AAT deficiency. Intercalated cells in the excretory pancreatic ducts may be an additional source of AAT.

Original languageEnglish
Pages (from-to)293-295
Number of pages3
JournalHuman Pathology
Issue number3
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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