Simultaneous alpha-1-antitrypsin accumulation in liver and pancreas

Francesco Callea; Johan Fevery; Valeer J. Desmet

doi:10.1016/S0046-8177(84)80195-1

Simultaneous alpha-1-antitrypsin accumulation in liver and pancreas

Francesco Callea, Johan Fevery, Valeer J. Desmet

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Inclusions positive for periodic acid-Schiff, resistant to diastase, and immunoreactive to alpha-1-antitrypsin (AAT) were found in hepatocytes and pancreatic islet cells of a patient with clinical and pathologic features of AAT deficiency. Alpha-1-antitrypsin was detected in all pancreatic islets, and AAT-positive cells were observed in the excretory pancreatic ducts. These findings suggest that the pancreas synthesizes AAT and possibly serves as a "storage" place in AAT deficiency. Intercalated cells in the excretory pancreatic ducts may be an additional source of AAT.

Original language	English
Pages (from-to)	293-295
Number of pages	3
Journal	Human Pathology
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/S0046-8177(84)80195-1
Publication status	Published - 1984

ASJC Scopus subject areas

Pathology and Forensic Medicine

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AU - Callea, Francesco

AU - Fevery, Johan

AU - Desmet, Valeer J.

PY - 1984

Y1 - 1984

N2 - Inclusions positive for periodic acid-Schiff, resistant to diastase, and immunoreactive to alpha-1-antitrypsin (AAT) were found in hepatocytes and pancreatic islet cells of a patient with clinical and pathologic features of AAT deficiency. Alpha-1-antitrypsin was detected in all pancreatic islets, and AAT-positive cells were observed in the excretory pancreatic ducts. These findings suggest that the pancreas synthesizes AAT and possibly serves as a "storage" place in AAT deficiency. Intercalated cells in the excretory pancreatic ducts may be an additional source of AAT.

AB - Inclusions positive for periodic acid-Schiff, resistant to diastase, and immunoreactive to alpha-1-antitrypsin (AAT) were found in hepatocytes and pancreatic islet cells of a patient with clinical and pathologic features of AAT deficiency. Alpha-1-antitrypsin was detected in all pancreatic islets, and AAT-positive cells were observed in the excretory pancreatic ducts. These findings suggest that the pancreas synthesizes AAT and possibly serves as a "storage" place in AAT deficiency. Intercalated cells in the excretory pancreatic ducts may be an additional source of AAT.

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Simultaneous alpha-1-antitrypsin accumulation in liver and pancreas

Abstract

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