Abstract
Inclusions positive for periodic acid-Schiff, resistant to diastase, and immunoreactive to alpha-1-antitrypsin (AAT) were found in hepatocytes and pancreatic islet cells of a patient with clinical and pathologic features of AAT deficiency. Alpha-1-antitrypsin was detected in all pancreatic islets, and AAT-positive cells were observed in the excretory pancreatic ducts. These findings suggest that the pancreas synthesizes AAT and possibly serves as a "storage" place in AAT deficiency. Intercalated cells in the excretory pancreatic ducts may be an additional source of AAT.
Original language | English |
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Pages (from-to) | 293-295 |
Number of pages | 3 |
Journal | Human Pathology |
Volume | 15 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1984 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine