Simultaneous circadian variations of plasma ACTH, beta-lipotropin, beta-endorphin and cortisol

Felice Petraglia, Fabio Facchinetti, Donatella Parrini, Giuseppe Micieli, Salvatore De Luca, Andrea R. Genazzani

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The major objective of this study was to investigate the analogy existing between the typical circadian periodicity of ACTH and that recently described of β-lipotropin (β-LPH) and β-endorphin (β-EP) plasma levels. The determination of their concentrations, plus cortisol, has been performed on the same plasma samples of 6 healthy volunteers. All hormones were measured by radioimmunoassay. Those of β-LPH and β-EP were preceded by a purification of plasma through silicic acid extraction and Sephadex G-75 gel filtration. The highest values (mean ± SEM) were found in the morning (ACTH: 10.3 ± 0.9; β-LPH: 6.3 ± 0.7; β-EP: 6.5 ± 0.5 fmol/ml; cortisol: 378 ± 30 pmol/ml) and the lowest values in the evening (ACTH: 6.1 ± 0.7; β-LPH: 3.3 ± 0.4; β-EP: 3.7 ± 0.6 fmol/ml; cortisol: 130 ± 23 pmol/ml). Statistical analysis using the Fourier method led to the evidence of a concomitant circadian secretory pattern of the three proopiocortin-related peptides. These results strongly suggest that the phasic secretion of ACTH. β-LPH and β-EP underlies a common central control.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalHormone Research in Paediatrics
Volume17
Issue number3
Publication statusPublished - 1983

Fingerprint

beta-Lipotropin
beta-Endorphin
Adrenocorticotropic Hormone
Hydrocortisone
Silicic Acid
Endorphins
Pro-Opiomelanocortin
Periodicity
Fourier Analysis
Radioimmunoassay
Gel Chromatography
Healthy Volunteers
Hormones
Peptides

Keywords

  • ACTH
  • Circadian rhythm
  • Cortisol
  • β-Endorphin
  • β-Lipotropin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Petraglia, F., Facchinetti, F., Parrini, D., Micieli, G., De Luca, S., & Genazzani, A. R. (1983). Simultaneous circadian variations of plasma ACTH, beta-lipotropin, beta-endorphin and cortisol. Hormone Research in Paediatrics, 17(3), 147-152.

Simultaneous circadian variations of plasma ACTH, beta-lipotropin, beta-endorphin and cortisol. / Petraglia, Felice; Facchinetti, Fabio; Parrini, Donatella; Micieli, Giuseppe; De Luca, Salvatore; Genazzani, Andrea R.

In: Hormone Research in Paediatrics, Vol. 17, No. 3, 1983, p. 147-152.

Research output: Contribution to journalArticle

Petraglia, F, Facchinetti, F, Parrini, D, Micieli, G, De Luca, S & Genazzani, AR 1983, 'Simultaneous circadian variations of plasma ACTH, beta-lipotropin, beta-endorphin and cortisol', Hormone Research in Paediatrics, vol. 17, no. 3, pp. 147-152.
Petraglia, Felice ; Facchinetti, Fabio ; Parrini, Donatella ; Micieli, Giuseppe ; De Luca, Salvatore ; Genazzani, Andrea R. / Simultaneous circadian variations of plasma ACTH, beta-lipotropin, beta-endorphin and cortisol. In: Hormone Research in Paediatrics. 1983 ; Vol. 17, No. 3. pp. 147-152.
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