TY - JOUR
T1 - Simultaneous evaluation of the circulating levels of both Th1 and Th2 chemokines in patients with autoimmune Addison's disease
AU - Bellastella, G.
AU - Rotondi, M.
AU - Pane, E.
AU - Costantini, S.
AU - Colella, C.
AU - Calemma, R.
AU - Capone, F.
AU - Falorni, A.
AU - Castello, G.
AU - Sinisi, A. A.
AU - Bizzarro, A.
AU - Chiovato, L.
AU - Bellastella, A.
AU - De Bellis, A.
PY - 2011/12
Y1 - 2011/12
N2 - Background: Chemokines play a key role in the recruitment of the immune cells into the autoimmune process. Thus, the simultaneous evaluation of circulating levels of Th1-related chemokines, such as CX chemokine ligand 10 (CXCL10) and macrophage inflammatory proteins 1α (CCL3/MIP-1α), and Th2-related chemokines, such as macrophage inflammatory proteins 1 β (CCL4/MIP-1β) could be useful in the approach to some autoimmune diseases, including autoimmune Addison's disease (AAD). Aim: To evaluate plasmatic levels of MIP-1α, MIP-1β, CXCL10 and adrenocortical antibodies in patients with AAD under treatment with corticosteroids. Patients and methods: Twelve women and 5 men (group 1) were divided-in 2 subgroups: 9 subsjects with isolated AAD (group 1a) and 8 with AAD associated with chronic autoimmune thyroiditis (group 1b). MIP-1α, MIP-1β and CXCL10 were evaluated in the serum of all patients and in 20 healthy controls, using a system for microarray suspension. Results: The levels of MIP-1α, MIP-1β and CXCL10 resulted significantly increased vs controls (p
AB - Background: Chemokines play a key role in the recruitment of the immune cells into the autoimmune process. Thus, the simultaneous evaluation of circulating levels of Th1-related chemokines, such as CX chemokine ligand 10 (CXCL10) and macrophage inflammatory proteins 1α (CCL3/MIP-1α), and Th2-related chemokines, such as macrophage inflammatory proteins 1 β (CCL4/MIP-1β) could be useful in the approach to some autoimmune diseases, including autoimmune Addison's disease (AAD). Aim: To evaluate plasmatic levels of MIP-1α, MIP-1β, CXCL10 and adrenocortical antibodies in patients with AAD under treatment with corticosteroids. Patients and methods: Twelve women and 5 men (group 1) were divided-in 2 subgroups: 9 subsjects with isolated AAD (group 1a) and 8 with AAD associated with chronic autoimmune thyroiditis (group 1b). MIP-1α, MIP-1β and CXCL10 were evaluated in the serum of all patients and in 20 healthy controls, using a system for microarray suspension. Results: The levels of MIP-1α, MIP-1β and CXCL10 resulted significantly increased vs controls (p
KW - Hypoadrenalism
KW - Thyroid and adrenal autoimmunity
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U2 - 10.3275/7414
DO - 10.3275/7414
M3 - Article
C2 - 21169727
AN - SCOPUS:84858025298
VL - 34
SP - 831
EP - 834
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 11
ER -