Simultaneous evaluation of the circulating levels of both Th1 and Th2 chemokines in patients with autoimmune Addison's disease

G. Bellastella, M. Rotondi, E. Pane, S. Costantini, C. Colella, R. Calemma, F. Capone, A. Falorni, G. Castello, A. A. Sinisi, A. Bizzarro, L. Chiovato, A. Bellastella, A. De Bellis

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Chemokines play a key role in the recruitment of the immune cells into the autoimmune process. Thus, the simultaneous evaluation of circulating levels of Th1-related chemokines, such as CX chemokine ligand 10 (CXCL10) and macrophage inflammatory proteins 1α (CCL3/MIP-1α), and Th2-related chemokines, such as macrophage inflammatory proteins 1 β (CCL4/MIP-1β) could be useful in the approach to some autoimmune diseases, including autoimmune Addison's disease (AAD). Aim: To evaluate plasmatic levels of MIP-1α, MIP-1β, CXCL10 and adrenocortical antibodies in patients with AAD under treatment with corticosteroids. Patients and methods: Twelve women and 5 men (group 1) were divided-in 2 subgroups: 9 subsjects with isolated AAD (group 1a) and 8 with AAD associated with chronic autoimmune thyroiditis (group 1b). MIP-1α, MIP-1β and CXCL10 were evaluated in the serum of all patients and in 20 healthy controls, using a system for microarray suspension. Results: The levels of MIP-1α, MIP-1β and CXCL10 resulted significantly increased vs controls (p

Original languageEnglish
Pages (from-to)831-834
Number of pages4
JournalJournal of Endocrinological Investigation
Volume34
Issue number11
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Hypoadrenalism
  • Thyroid and adrenal autoimmunity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Simultaneous evaluation of the circulating levels of both Th1 and Th2 chemokines in patients with autoimmune Addison's disease'. Together they form a unique fingerprint.

Cite this