Simultaneous Integrated Boost in Once-weekly Hypofractionated Radiotherapy for Breast Cancer in the Elderly: Preliminary evidence

Elisabetta Bonzano; Liliana Belgioia; Giorgia Polizzi; Guido Siffredi; Piero Fregatti; Daniele Friedman; Stefania Garelli; Marco Gusinu; Elena Maria Luisa Vaccara; Marina Guenzi; Renzo Corvò

doi:10.21873/invivo.11694

Simultaneous Integrated Boost in Once-weekly Hypofractionated Radiotherapy for Breast Cancer in the Elderly: Preliminary evidence

Elisabetta Bonzano, Liliana Belgioia, Giorgia Polizzi, Guido Siffredi, Piero Fregatti, Daniele Friedman, Stefania Garelli, Marco Gusinu, Elena Maria Luisa Vaccara, Marina Guenzi, Renzo Corvò

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: To evaluate once-weekly hypofractionated radiotherapy in elderly patients affected by early breast cancer, reporting acute and late toxicity profiles, and treatment feasibility. Patients and Methods: Fifty patients were treated with a hypofractionated regimen: 28.5±2.5 Gy in five fractions at one fraction weekly. Simultaneous integrated boost (SIB) to the tumor bed in high-risk cases. Inclusion criteria: patients over 70 years old, pT1-2, N0-1a. Acute and late toxicities were assessed based on Radiation Therapy Oncology Group. Results: The median follow-up was 20 months and the median patient age was 79 years. SIB was added for 22 patients (44%). Grade 3-4 acute cutaneous toxicities were not observed; grade 2 toxicity occurred only in four patients (8%). Late subcutaneous tissue toxicity consisted of grade 2 fibrosis in two patients (4%), grade 1 in five (10%) and grade 0 in 41(85%). Conclusion: Limiting fraction numbers with a safer profile may improve the management of breast cancer for the elderly.

Original language	English
Pages (from-to)	1985-1992
Number of pages	8
Journal	In Vivo
Volume	33
Issue number	6
DOIs	https://doi.org/10.21873/invivo.11694
Publication status	Published - Jan 1 2019

Keywords

Breast cancer
Elderly
Hypofractionation
Radiotherapy

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology

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Simultaneous Integrated Boost in Once-weekly Hypofractionated Radiotherapy for Breast Cancer in the Elderly : Preliminary evidence. / Bonzano, Elisabetta; Belgioia, Liliana; Polizzi, Giorgia; Siffredi, Guido; Fregatti, Piero ; Friedman, Daniele; Garelli, Stefania; Gusinu, Marco; Vaccara, Elena Maria Luisa; Guenzi, Marina; Corvò, Renzo.

In: In Vivo, Vol. 33, No. 6, 01.01.2019, p. 1985-1992.

Research output: Contribution to journal › Article › peer-review

Bonzano, Elisabetta ; Belgioia, Liliana ; Polizzi, Giorgia ; Siffredi, Guido ; Fregatti, Piero ; Friedman, Daniele ; Garelli, Stefania ; Gusinu, Marco ; Vaccara, Elena Maria Luisa ; Guenzi, Marina ; Corvò, Renzo. / Simultaneous Integrated Boost in Once-weekly Hypofractionated Radiotherapy for Breast Cancer in the Elderly : Preliminary evidence. In: In Vivo. 2019 ; Vol. 33, No. 6. pp. 1985-1992.

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abstract = "Aim: To evaluate once-weekly hypofractionated radiotherapy in elderly patients affected by early breast cancer, reporting acute and late toxicity profiles, and treatment feasibility. Patients and Methods: Fifty patients were treated with a hypofractionated regimen: 28.5±2.5 Gy in five fractions at one fraction weekly. Simultaneous integrated boost (SIB) to the tumor bed in high-risk cases. Inclusion criteria: patients over 70 years old, pT1-2, N0-1a. Acute and late toxicities were assessed based on Radiation Therapy Oncology Group. Results: The median follow-up was 20 months and the median patient age was 79 years. SIB was added for 22 patients (44%). Grade 3-4 acute cutaneous toxicities were not observed; grade 2 toxicity occurred only in four patients (8%). Late subcutaneous tissue toxicity consisted of grade 2 fibrosis in two patients (4%), grade 1 in five (10%) and grade 0 in 41(85%). Conclusion: Limiting fraction numbers with a safer profile may improve the management of breast cancer for the elderly.",

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AU - Siffredi, Guido

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AU - Friedman, Daniele

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AU - Corvò, Renzo

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AB - Aim: To evaluate once-weekly hypofractionated radiotherapy in elderly patients affected by early breast cancer, reporting acute and late toxicity profiles, and treatment feasibility. Patients and Methods: Fifty patients were treated with a hypofractionated regimen: 28.5±2.5 Gy in five fractions at one fraction weekly. Simultaneous integrated boost (SIB) to the tumor bed in high-risk cases. Inclusion criteria: patients over 70 years old, pT1-2, N0-1a. Acute and late toxicities were assessed based on Radiation Therapy Oncology Group. Results: The median follow-up was 20 months and the median patient age was 79 years. SIB was added for 22 patients (44%). Grade 3-4 acute cutaneous toxicities were not observed; grade 2 toxicity occurred only in four patients (8%). Late subcutaneous tissue toxicity consisted of grade 2 fibrosis in two patients (4%), grade 1 in five (10%) and grade 0 in 41(85%). Conclusion: Limiting fraction numbers with a safer profile may improve the management of breast cancer for the elderly.

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Simultaneous Integrated Boost in Once-weekly Hypofractionated Radiotherapy for Breast Cancer in the Elderly: Preliminary evidence

Abstract

Keywords

ASJC Scopus subject areas

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