Simultaneous Integrated Boost in Once-weekly Hypofractionated Radiotherapy for Breast Cancer in the Elderly: Preliminary evidence

Elisabetta Bonzano, Liliana Belgioia, Giorgia Polizzi, Guido Siffredi, Piero Fregatti, Daniele Friedman, Stefania Garelli, Marco Gusinu, Elena Maria Luisa Vaccara, Marina Guenzi, Renzo Corvò

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To evaluate once-weekly hypofractionated radiotherapy in elderly patients affected by early breast cancer, reporting acute and late toxicity profiles, and treatment feasibility. Patients and Methods: Fifty patients were treated with a hypofractionated regimen: 28.5±2.5 Gy in five fractions at one fraction weekly. Simultaneous integrated boost (SIB) to the tumor bed in high-risk cases. Inclusion criteria: patients over 70 years old, pT1-2, N0-1a. Acute and late toxicities were assessed based on Radiation Therapy Oncology Group. Results: The median follow-up was 20 months and the median patient age was 79 years. SIB was added for 22 patients (44%). Grade 3-4 acute cutaneous toxicities were not observed; grade 2 toxicity occurred only in four patients (8%). Late subcutaneous tissue toxicity consisted of grade 2 fibrosis in two patients (4%), grade 1 in five (10%) and grade 0 in 41(85%). Conclusion: Limiting fraction numbers with a safer profile may improve the management of breast cancer for the elderly.

Original languageEnglish
Pages (from-to)1985-1992
Number of pages8
JournalIn Vivo
Volume33
Issue number6
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Breast cancer
  • Elderly
  • Hypofractionation
  • Radiotherapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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