Simultaneous measurement of beat-to-beat carotid diameter and pressure changes to assess arterial mechanical properties

Cristina Giannattasio, Paolo Salvi, Filippo Valbusa, Anna Kearney-Schwartz, Anna Capra, Maria Amigoni, Monica Failla, Lucia Boffi, Fabiana Madotto, Athanasios Benetos, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

Use of local arterial distensibility measurements by change in carotid artery diameter divided by pulse pressure has limitations because blood pressure is often taken in a vessel distant or at a time different from where and when change in diameter is taken. In 92 subjects (23 to 91 years of age), carotid artery diameter was continuously measured ecographically, whereas blood pressure was continuously measured simultaneously tonometrically on the contralateral artery, the 2 signals being synchronized via 2 EKGs. Within each cardiac cycle, there was a linear relationship between the changes in vessel diameter and the changes in blood pressure during either the protomesosystole or the diastole after the dicrotic notch. The diastolic slope was displaced upward and steeper than the systolic slope, the pressure-diameter loop showing a hysteresis. Both slopes showed a high reproducibility when data were averaged over a several-second period. There were small differences between consecutive cardiac cycles, suggesting that modulation of arterial mechanical response to continuous changes in intravascular pressure may undergo physiological variations. In the 92 subjects, systolic and diastolic slopes correlated significantly with distensibility values obtained by Reneman formula and exhibited a close inverse relationship with each subject's age and systolic blood pressure, thereby showing the ability to reflect age- and pressure-dependent large artery stiffening. This method may allow precise assessment of man's arterial mechanical properties within each cardiac cycle. This highly dynamic assessment may help to collect information on properties of normal and altered large elastic arteries and the mechanisms involved in disease.

Original languageEnglish
Pages (from-to)896-902
Number of pages7
JournalHypertension
Volume52
Issue number5
DOIs
Publication statusPublished - Nov 2008

Keywords

  • Aging
  • Arterial compliance
  • Arterial distensibility
  • Arterial mechanical properties
  • New method
  • Stiffness
  • Systolic blood pressure

ASJC Scopus subject areas

  • Internal Medicine

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