TY - JOUR
T1 - Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases
AU - Campidelli, Cristina
AU - Sabattini, Elena
AU - Piccioli, Milena
AU - Rossi, Maura
AU - De Blasi, Donatella
AU - Miraglia, Eustachio
AU - Rodriguez-Abreu, Delvys
AU - Franscini, Leda Leoncini
AU - Bertoni, Francesco
AU - Mazzucchelli, Luca
AU - Cavalli, Franco
AU - Zucca, Emanuele
AU - Pileri, Stefano A.
PY - 2007/5
Y1 - 2007/5
N2 - We report on 2 composite lymphomas occurring in elderly patients, morphologically characterized by the combination of peripheral T-cell lymphoma (PTCL) unspecified and B-cell small lymphocytic lymphoma. Immunohistochemistry provided objective confirmation of the coexistence of the 2 malignancies, as did molecular biology by revealing clonal T-cell receptor γ and immunoglobulin heavy chain gene rearrangements. One of the patients had no history of indolent lymphoma either at the personal and family level, whereas the other showed a strong familial predisposition, his mother and sister having suffered from B-cell chronic lymphocytic leukemia. Epstein-Barr virus was detected in the PTCL component of 1 case, but was negative in the other. To the best of our knowledge, the simultaneous occurrence of PTCL unspecified and B-cell small lymphocytic lymphoma is an exceptional event; the possible pathogenetic correlations between the 2 neoplasms are discussed.
AB - We report on 2 composite lymphomas occurring in elderly patients, morphologically characterized by the combination of peripheral T-cell lymphoma (PTCL) unspecified and B-cell small lymphocytic lymphoma. Immunohistochemistry provided objective confirmation of the coexistence of the 2 malignancies, as did molecular biology by revealing clonal T-cell receptor γ and immunoglobulin heavy chain gene rearrangements. One of the patients had no history of indolent lymphoma either at the personal and family level, whereas the other showed a strong familial predisposition, his mother and sister having suffered from B-cell chronic lymphocytic leukemia. Epstein-Barr virus was detected in the PTCL component of 1 case, but was negative in the other. To the best of our knowledge, the simultaneous occurrence of PTCL unspecified and B-cell small lymphocytic lymphoma is an exceptional event; the possible pathogenetic correlations between the 2 neoplasms are discussed.
KW - B-cell chronic lymphocytic leukemia/B-cell small lymphocytic lymphoma
KW - Composite lymphoma
KW - EBV
KW - Peripheral T-cell lymphoma
UR - http://www.scopus.com/inward/record.url?scp=34147134566&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34147134566&partnerID=8YFLogxK
U2 - 10.1016/j.humpath.2006.10.010
DO - 10.1016/j.humpath.2006.10.010
M3 - Article
C2 - 17270243
AN - SCOPUS:34147134566
VL - 38
SP - 787
EP - 792
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 5
ER -