Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases

Cristina Campidelli; Elena Sabattini; Milena Piccioli; Maura Rossi; Donatella De Blasi; Eustachio Miraglia; Delvys Rodriguez-Abreu; Leda Leoncini Franscini; Francesco Bertoni; Luca Mazzucchelli; Franco Cavalli; Emanuele Zucca; Stefano A. Pileri

doi:10.1016/j.humpath.2006.10.010

Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases

Cristina Campidelli, Elena Sabattini, Milena Piccioli, Maura Rossi, Donatella De Blasi, Eustachio Miraglia, Delvys Rodriguez-Abreu, Leda Leoncini Franscini, Francesco Bertoni, Luca Mazzucchelli, Franco Cavalli, Emanuele Zucca, Stefano A. Pileri

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article

Abstract

We report on 2 composite lymphomas occurring in elderly patients, morphologically characterized by the combination of peripheral T-cell lymphoma (PTCL) unspecified and B-cell small lymphocytic lymphoma. Immunohistochemistry provided objective confirmation of the coexistence of the 2 malignancies, as did molecular biology by revealing clonal T-cell receptor γ and immunoglobulin heavy chain gene rearrangements. One of the patients had no history of indolent lymphoma either at the personal and family level, whereas the other showed a strong familial predisposition, his mother and sister having suffered from B-cell chronic lymphocytic leukemia. Epstein-Barr virus was detected in the PTCL component of 1 case, but was negative in the other. To the best of our knowledge, the simultaneous occurrence of PTCL unspecified and B-cell small lymphocytic lymphoma is an exceptional event; the possible pathogenetic correlations between the 2 neoplasms are discussed.

Original language	English
Pages (from-to)	787-792
Number of pages	6
Journal	Human Pathology
Volume	38
Issue number	5
DOIs	https://doi.org/10.1016/j.humpath.2006.10.010
Publication status	Published - May 2007

Keywords

B-cell chronic lymphocytic leukemia/B-cell small lymphocytic lymphoma
Composite lymphoma
EBV
Peripheral T-cell lymphoma

ASJC Scopus subject areas

Pathology and Forensic Medicine

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Campidelli, C., Sabattini, E., Piccioli, M., Rossi, M., De Blasi, D., Miraglia, E., Rodriguez-Abreu, D., Franscini, L. L., Bertoni, F., Mazzucchelli, L., Cavalli, F., Zucca, E., & Pileri, S. A. (2007). Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases. Human Pathology, 38(5), 787-792. https://doi.org/10.1016/j.humpath.2006.10.010

Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases. / Campidelli, Cristina; Sabattini, Elena; Piccioli, Milena; Rossi, Maura; De Blasi, Donatella; Miraglia, Eustachio; Rodriguez-Abreu, Delvys; Franscini, Leda Leoncini; Bertoni, Francesco; Mazzucchelli, Luca; Cavalli, Franco; Zucca, Emanuele; Pileri, Stefano A.

In: Human Pathology, Vol. 38, No. 5, 05.2007, p. 787-792.

Research output: Contribution to journal › Article

Campidelli, C, Sabattini, E, Piccioli, M, Rossi, M, De Blasi, D, Miraglia, E, Rodriguez-Abreu, D, Franscini, LL, Bertoni, F, Mazzucchelli, L, Cavalli, F, Zucca, E & Pileri, SA 2007, 'Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases', Human Pathology, vol. 38, no. 5, pp. 787-792. https://doi.org/10.1016/j.humpath.2006.10.010

Campidelli, Cristina ; Sabattini, Elena ; Piccioli, Milena ; Rossi, Maura ; De Blasi, Donatella ; Miraglia, Eustachio ; Rodriguez-Abreu, Delvys ; Franscini, Leda Leoncini ; Bertoni, Francesco ; Mazzucchelli, Luca ; Cavalli, Franco ; Zucca, Emanuele ; Pileri, Stefano A. / Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases. In: Human Pathology. 2007 ; Vol. 38, No. 5. pp. 787-792.

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abstract = "We report on 2 composite lymphomas occurring in elderly patients, morphologically characterized by the combination of peripheral T-cell lymphoma (PTCL) unspecified and B-cell small lymphocytic lymphoma. Immunohistochemistry provided objective confirmation of the coexistence of the 2 malignancies, as did molecular biology by revealing clonal T-cell receptor γ and immunoglobulin heavy chain gene rearrangements. One of the patients had no history of indolent lymphoma either at the personal and family level, whereas the other showed a strong familial predisposition, his mother and sister having suffered from B-cell chronic lymphocytic leukemia. Epstein-Barr virus was detected in the PTCL component of 1 case, but was negative in the other. To the best of our knowledge, the simultaneous occurrence of PTCL unspecified and B-cell small lymphocytic lymphoma is an exceptional event; the possible pathogenetic correlations between the 2 neoplasms are discussed.",

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