Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases

Cristina Campidelli, Elena Sabattini, Milena Piccioli, Maura Rossi, Donatella De Blasi, Eustachio Miraglia, Delvys Rodriguez-Abreu, Leda Leoncini Franscini, Francesco Bertoni, Luca Mazzucchelli, Franco Cavalli, Emanuele Zucca, Stefano A. Pileri

Research output: Contribution to journalArticle

Abstract

We report on 2 composite lymphomas occurring in elderly patients, morphologically characterized by the combination of peripheral T-cell lymphoma (PTCL) unspecified and B-cell small lymphocytic lymphoma. Immunohistochemistry provided objective confirmation of the coexistence of the 2 malignancies, as did molecular biology by revealing clonal T-cell receptor γ and immunoglobulin heavy chain gene rearrangements. One of the patients had no history of indolent lymphoma either at the personal and family level, whereas the other showed a strong familial predisposition, his mother and sister having suffered from B-cell chronic lymphocytic leukemia. Epstein-Barr virus was detected in the PTCL component of 1 case, but was negative in the other. To the best of our knowledge, the simultaneous occurrence of PTCL unspecified and B-cell small lymphocytic lymphoma is an exceptional event; the possible pathogenetic correlations between the 2 neoplasms are discussed.

Original languageEnglish
Pages (from-to)787-792
Number of pages6
JournalHuman Pathology
Volume38
Issue number5
DOIs
Publication statusPublished - May 2007

Keywords

  • B-cell chronic lymphocytic leukemia/B-cell small lymphocytic lymphoma
  • Composite lymphoma
  • EBV
  • Peripheral T-cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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  • Cite this

    Campidelli, C., Sabattini, E., Piccioli, M., Rossi, M., De Blasi, D., Miraglia, E., Rodriguez-Abreu, D., Franscini, L. L., Bertoni, F., Mazzucchelli, L., Cavalli, F., Zucca, E., & Pileri, S. A. (2007). Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases. Human Pathology, 38(5), 787-792. https://doi.org/10.1016/j.humpath.2006.10.010