Simultaneous pancreas-kidney transplantation: Short- and long-term results

E. Orsenigo, C. Socci, P. Fiorina, M. Cristallo, R. Castoldi, F. Gavazzi, E. La Rocca, L. Invernizzi, A. Secchi, V. Di Carlo

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Abstract

Simultaneous kidney and pancreas transplantation (SKPT) is the treatment of choice for a majority of type I diabetic patients with end-stage renal disease. With continual refinements in surgical technique and an evolving immunosuppressive arsenal, graft and patient survival have continually improved. The purpose of this study was to evaluate the short- and long-term results of SKPTs performed in 174 recipients from June 1985 to March 2003 including 37 segmental grafts with duct occlusion, 73 whole pancreas transplants with bladder diversion, and 64 whole pancreas grafts with enteric diversion. The series includes 160 cases with systemic drainage and 14 with portal drainage. In the segmental pancreas group, patient survival was 85%, 76%, and 53% with pancreas survival of 67%, 36%, and 15%, and kidney survival of 82%, 63%, and 15%, respectively, at 1, 5, and 10 years. Among the bladder diversion group, patient survival was 94%, 83%, and 73% pancreas survival 72%, 67%, and 65%, and kidney survival 89%, 78%, and 58%, respectively, 1, 5, and 10 years. Among the enter diversion group patient survival was 90% and 90% at 12 and 108 months, pancreas survival 80% and 65%, and kidney survival 85% and 85%, respectively. There were significant differences between curves of survival distribution according to the surgical technique applied for patients (P = .04), pancreas (P = .007), and kidney (P = .005). Based on the results from our study, the short- and long-term prognosis after SKPT is satisfactory, especially compared to the outcomes of long-term dialysis among patients with end-stage renal disease caused by type I diabetes.

Original languageEnglish
Pages (from-to)586-588
Number of pages3
JournalTransplantation Proceedings
Volume36
Issue number3
DOIs
Publication statusPublished - Apr 2004

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Pancreas Transplantation
Kidney Transplantation
Pancreas
Kidney
Survival
Transplants
Chronic Kidney Failure
Drainage
Urinary Bladder
Graft Survival
Immunosuppressive Agents
Type 1 Diabetes Mellitus
Dialysis

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Simultaneous pancreas-kidney transplantation : Short- and long-term results. / Orsenigo, E.; Socci, C.; Fiorina, P.; Cristallo, M.; Castoldi, R.; Gavazzi, F.; La Rocca, E.; Invernizzi, L.; Secchi, A.; Di Carlo, V.

In: Transplantation Proceedings, Vol. 36, No. 3, 04.2004, p. 586-588.

Research output: Contribution to journalArticle

Orsenigo, E, Socci, C, Fiorina, P, Cristallo, M, Castoldi, R, Gavazzi, F, La Rocca, E, Invernizzi, L, Secchi, A & Di Carlo, V 2004, 'Simultaneous pancreas-kidney transplantation: Short- and long-term results', Transplantation Proceedings, vol. 36, no. 3, pp. 586-588. https://doi.org/10.1016/j.transproceed.2004.02.041
Orsenigo, E. ; Socci, C. ; Fiorina, P. ; Cristallo, M. ; Castoldi, R. ; Gavazzi, F. ; La Rocca, E. ; Invernizzi, L. ; Secchi, A. ; Di Carlo, V. / Simultaneous pancreas-kidney transplantation : Short- and long-term results. In: Transplantation Proceedings. 2004 ; Vol. 36, No. 3. pp. 586-588.
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AU - Gavazzi, F.

AU - La Rocca, E.

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