Abstract
Abstract Purpose To evaluate the role of simultaneous hybrid PET/MR imaging and to correlate metabolic PET data with morpho-functional parameters derived by MRI in patients with head-neck cancer. Methods Forty-four patients, with histologically confirmed head and neck malignancy (22 primary tumors and 22 follow-up) were studied. Patients initially received a clinical exam and endoscopy with direct biopsy. Next patients underwent whole body PET/CT followed by PET/MR of the head/neck region. PET and MRI studies were separately evaluated by two blinded groups (both included one radiologist and one nuclear physician) in order to define the presence or absence of lesions/recurrences. Regions of interest (ROIs) analysis was conducted on the primary lesion at the level of maximum size on metabolic (SUV and MTV), diffusion (ADC) and perfusion (Ktrans, Ve, kep and iAUC) parameters. Results PET/MR examinations were successfully performed on all 44 patients. Agreement between the two blinded groups was found in anatomic allocation of lesions by PET/MR (Primary tumors: Cohen's kappa 0.93; Follow-up: Cohen's kappa 0.89). There was a significant correlation between CT-SUV measures and MR (e.g., CT-SUV VOI vs. MR-SUV VOI: ρ = 0.97, p <0.001 for the entire sample). There was also significant positive correlations between the ROI area, SUV measures, and the metabolic parameters (SUV and MTV) obtained during both PET/CT and PET/MR. A significant negative correlation was observed between ADC and Ktrans values in the primary tumors. In addition, a significant negative correlation existed between MR SUV and ADC in recurrent tumors. Conclusion Our study demonstrates the feasibility of PET/MR imaging for primary tumors and recurrent tumors evaluations of head/neck malignant lesions. When assessing HNC, PET/MR allows simultaneous collection of multiparametric metabolic and functional data. This technique therefore allows for a more complete characterization of malignant lesions.
| Original language | English |
|---|---|
| Article number | 7097 |
| Pages (from-to) | 1269-1276 |
| Number of pages | 8 |
| Journal | European Journal of Radiology |
| Volume | 84 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2015 |
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Keywords
- DCE
- DWI
- Head and neck cancer
- Hybrid imaging
- PET/MR
- SUV
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Simultaneous PET/MR head-neck cancer imaging : Preliminary clinical experience and multiparametric evaluation. / Covello, M.; Cavaliere, C.; Aiello, M.; Cianelli, M. S.; Mesolella, M.; Iorio, B.; Rossi, A.; Nicolai, E.
In: European Journal of Radiology, Vol. 84, No. 7, 7097, 01.07.2015, p. 1269-1276.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simultaneous PET/MR head-neck cancer imaging
T2 - Preliminary clinical experience and multiparametric evaluation
AU - Covello, M.
AU - Cavaliere, C.
AU - Aiello, M.
AU - Cianelli, M. S.
AU - Mesolella, M.
AU - Iorio, B.
AU - Rossi, A.
AU - Nicolai, E.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Abstract Purpose To evaluate the role of simultaneous hybrid PET/MR imaging and to correlate metabolic PET data with morpho-functional parameters derived by MRI in patients with head-neck cancer. Methods Forty-four patients, with histologically confirmed head and neck malignancy (22 primary tumors and 22 follow-up) were studied. Patients initially received a clinical exam and endoscopy with direct biopsy. Next patients underwent whole body PET/CT followed by PET/MR of the head/neck region. PET and MRI studies were separately evaluated by two blinded groups (both included one radiologist and one nuclear physician) in order to define the presence or absence of lesions/recurrences. Regions of interest (ROIs) analysis was conducted on the primary lesion at the level of maximum size on metabolic (SUV and MTV), diffusion (ADC) and perfusion (Ktrans, Ve, kep and iAUC) parameters. Results PET/MR examinations were successfully performed on all 44 patients. Agreement between the two blinded groups was found in anatomic allocation of lesions by PET/MR (Primary tumors: Cohen's kappa 0.93; Follow-up: Cohen's kappa 0.89). There was a significant correlation between CT-SUV measures and MR (e.g., CT-SUV VOI vs. MR-SUV VOI: ρ = 0.97, p <0.001 for the entire sample). There was also significant positive correlations between the ROI area, SUV measures, and the metabolic parameters (SUV and MTV) obtained during both PET/CT and PET/MR. A significant negative correlation was observed between ADC and Ktrans values in the primary tumors. In addition, a significant negative correlation existed between MR SUV and ADC in recurrent tumors. Conclusion Our study demonstrates the feasibility of PET/MR imaging for primary tumors and recurrent tumors evaluations of head/neck malignant lesions. When assessing HNC, PET/MR allows simultaneous collection of multiparametric metabolic and functional data. This technique therefore allows for a more complete characterization of malignant lesions.
AB - Abstract Purpose To evaluate the role of simultaneous hybrid PET/MR imaging and to correlate metabolic PET data with morpho-functional parameters derived by MRI in patients with head-neck cancer. Methods Forty-four patients, with histologically confirmed head and neck malignancy (22 primary tumors and 22 follow-up) were studied. Patients initially received a clinical exam and endoscopy with direct biopsy. Next patients underwent whole body PET/CT followed by PET/MR of the head/neck region. PET and MRI studies were separately evaluated by two blinded groups (both included one radiologist and one nuclear physician) in order to define the presence or absence of lesions/recurrences. Regions of interest (ROIs) analysis was conducted on the primary lesion at the level of maximum size on metabolic (SUV and MTV), diffusion (ADC) and perfusion (Ktrans, Ve, kep and iAUC) parameters. Results PET/MR examinations were successfully performed on all 44 patients. Agreement between the two blinded groups was found in anatomic allocation of lesions by PET/MR (Primary tumors: Cohen's kappa 0.93; Follow-up: Cohen's kappa 0.89). There was a significant correlation between CT-SUV measures and MR (e.g., CT-SUV VOI vs. MR-SUV VOI: ρ = 0.97, p <0.001 for the entire sample). There was also significant positive correlations between the ROI area, SUV measures, and the metabolic parameters (SUV and MTV) obtained during both PET/CT and PET/MR. A significant negative correlation was observed between ADC and Ktrans values in the primary tumors. In addition, a significant negative correlation existed between MR SUV and ADC in recurrent tumors. Conclusion Our study demonstrates the feasibility of PET/MR imaging for primary tumors and recurrent tumors evaluations of head/neck malignant lesions. When assessing HNC, PET/MR allows simultaneous collection of multiparametric metabolic and functional data. This technique therefore allows for a more complete characterization of malignant lesions.
KW - DCE
KW - DWI
KW - Head and neck cancer
KW - Hybrid imaging
KW - PET/MR
KW - SUV
UR - http://www.scopus.com/inward/record.url?scp=84930506808&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930506808&partnerID=8YFLogxK
U2 - 10.1016/j.ejrad.2015.04.010
DO - 10.1016/j.ejrad.2015.04.010
M3 - Article
C2 - 25958189
AN - SCOPUS:84930506808
VL - 84
SP - 1269
EP - 1276
JO - European Journal of Radiology
JF - European Journal of Radiology
SN - 0720-048X
IS - 7
M1 - 7097
ER -