Simultaneous PET/MRI assessment of response to cytotoxic and hormone neo-adjuvant chemotherapy in breast cancer: a preliminary report

V. Romeo, M. D’Aiuto, G. Frasci, M. Imbriaco, E. Nicolai

Research output: Contribution to journalArticle

Abstract

The aim of this study was to assess the response to cytotoxic and hormone neo-adjuvant chemotherapy in four patients with locally advanced breast cancer by simultaneous PET/MRI. Four patients with locally advanced breast cancer underwent simultaneous PET/MRI of the breast using a 3 T Biograph mMR before and after neo-adjuvant chemotherapy (two patients were treated with hormone-therapy and two patients were treated with cytotoxic chemotherapy). Morpho-structural tumoral features and tumor size were assessed; area value, metabolic (SUV and MTV) and functional (ADC, Ktrans, Ve, kep and iAUC) data were obtained by positioning regions of interest. A comparison of all parameters between the pre- and post-treatment PET/MRI examinations and between the two different therapeutic schedules was assessed. In patients treated with cytotoxic chemotherapy and classified as PR, there was a significant reduction of post-treatment morphological, metabolic and functional parameters. In a patient treated with hormone therapy, classified as SD, there was an increase of all post-treatment perfusion parameters, a substantially stable ADC value and a poor reduction of lesion size and of maximum SUV (SUVmax) values; the last patient, treated with hormone therapy and classified as PR, showed a significant reduction of lesion size and SUVmax values with a reduction of perfusion parameters and substantially stable ADC values. Multiparametric evaluation with simultaneous PET/MRI could be a useful tool to assess the response to cytotoxic and hormone neo-adjuvant chemotherapy in patients with breast cancer. Future studies in a larger cohort of patients are warranted to confirm the results of this preliminary study. © 2016, Springer Science+Business Media New York.
Original languageEnglish
JournalMedical Oncology
Volume34
Issue number2
DOIs
Publication statusPublished - Feb 2017

Keywords

  • Breast cancer
  • Neo-adjuvant chemotherapy
  • Simultaneous PET/MRI
  • cytotoxic agent
  • fluorodeoxyglucose f 18
  • hormone
  • antineoplastic agent
  • antineoplastic hormone agonists and antagonists
  • adult
  • aged
  • apparent diffusion coefficient
  • Article
  • breast cancer
  • breast carcinoma
  • cancer adjuvant therapy
  • cancer chemotherapy
  • cancer growth
  • cancer hormone therapy
  • cancer morphology
  • cancer patient
  • cancer size
  • case report
  • cytotoxicity
  • female
  • functional assessment
  • human
  • initial area under the concentration curve
  • metabolic tumor volume
  • middle aged
  • nuclear magnetic resonance imaging
  • oncological parameters
  • PET-MRI scanner
  • positron emission tomography
  • priority journal
  • standard uptake volume
  • treatment response
  • adjuvant chemotherapy
  • Breast Neoplasms
  • diagnostic imaging
  • multimodal imaging
  • neoadjuvant therapy
  • procedures
  • Adult
  • Aged
  • Antineoplastic Agents
  • Antineoplastic Agents, Hormonal
  • Chemotherapy, Adjuvant
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Multimodal Imaging
  • Neoadjuvant Therapy
  • Positron-Emission Tomography

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