Simultaneous PET/MRI in assessing the response to chemo/radiotherapy in head and neck carcinoma: initial experience

Valeria Romeo, Brigida Iorio, Massimo Mesolella, Lorenzo Ugga, Francesco Verde, Emanuele Nicolai, Mario Covello

Research output: Contribution to journalArticle

Abstract

The purpose of the study was to assess by simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) the response to chemotherapy (CHT) and/or radiotherapy (RT) in patients with head and neck squamous cell carcinoma (HNSCC). Five patients with HNSCC underwent simultaneous PET/MRI examination before and after CHT and/or RT. Standard uptake volume (SUV), apparent diffusion coefficient (ADC), Ktrans, Kep, Ve, and iAUC pre- and post-treatment values were extracted and compared. The response to treatment was assessed according to RECIST criteria and classified as complete response (CR), partial response (PR), stable disease (SD), and progression disease (PD). In patient 1, PR was observed with increased ADC, Ktrans, and Ve values and reduction of SUV, iAUC, and Kep values; during clinical and instrumental follow-up, the patient experienced disease progression. Patient 2, classified as PR, showed increased ADC values and reduction of SUV and all perfusion parameters; follow-up demonstrated disease stability. Patient 3, considered as SD, showed increase of ADC and all perfusion values with a mild decrease of SUV; PD was observed during clinical and instrumental follow-up. Patients 4 and 5 showed a CR with no detectable tumor lesions at post-treatment PET/MRI examination, confirmed by 1-year follow-up. Multiparametric evaluation with simultaneous PET/MRI could be a useful tool to assess and predict the response to CHT and/or RT in patients with HNSCC.

Original languageEnglish
Article number112
JournalMedical Oncology
Volume35
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Positron-Emission Tomography
Neck
Radiotherapy
Head
Magnetic Resonance Imaging
Carcinoma
Disease Progression
Drug Therapy
Perfusion
Therapeutics
Carcinoma, squamous cell of head and neck
Neoplasms

Keywords

  • Chemotherapy
  • Head and neck cancer
  • Radiotherapy
  • Simultaneous PET/MRI
  • Treatment response

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Simultaneous PET/MRI in assessing the response to chemo/radiotherapy in head and neck carcinoma : initial experience. / Romeo, Valeria; Iorio, Brigida; Mesolella, Massimo; Ugga, Lorenzo; Verde, Francesco; Nicolai, Emanuele; Covello, Mario.

In: Medical Oncology, Vol. 35, No. 7, 112, 01.07.2018.

Research output: Contribution to journalArticle

Romeo, Valeria ; Iorio, Brigida ; Mesolella, Massimo ; Ugga, Lorenzo ; Verde, Francesco ; Nicolai, Emanuele ; Covello, Mario. / Simultaneous PET/MRI in assessing the response to chemo/radiotherapy in head and neck carcinoma : initial experience. In: Medical Oncology. 2018 ; Vol. 35, No. 7.
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