Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity

Rocco Marchitelli, Marco Aiello, Arnaud Cachia, Mario Quarantelli, Carlo Cavaliere, Alfredo Postiglione, Gioacchino Tedeschi, Patrizia Montella, Graziella Milan, Marco Salvatore, Elena Salvatore, Jean Claude Baron, Sabina Pappatà

Research output: Contribution to journalArticle

Abstract

Simultaneously evaluating resting-state brain glucose metabolism and intrinsic functional activity has potential to impact the clinical neurosciences of Alzheimer Disease (AD). Indeed, integrating such combined information obtained in the same physiological setting may clarify how impairments in neuroenergetic and neuronal function interact and contribute to the mechanisms underlying AD. The present study used this multimodality approach to investigate, by means of a hybrid PET/MR scanner, the coupling between glucose consumption and intrinsic functional activity in 23 patients with AD-related cognitive impairment ranging from amnestic mild cognitive impairment (MCI) to mild-moderate AD (aMCI/AD), in comparison with a group of 23 healthy elderly controls. Between-group (Controls > Patients) comparisons were conducted on data from both imaging modalities using voxelwise 2-sample t-tests, corrected for partial-volume effects, head motion, age, gender and multiple tests. FDG-PET/fMRI relationships were assessed within and across subjects using Spearman partial correlations for three different resting-state fMRI (rs-fMRI) metrics sensitive to AD: fractional amplitude of low frequency fluctuations (fALFF), regional homogeneity (ReHo) and group independent component analysis with dual regression (gICA-DR). FDG and rs-fMRI metrics distinguished aMCI/AD from controls according to spatial patterns analogous to those found in stand-alone studies. Within-subject correlations were comparable across the three rs-fMRI metrics. Correlations were overall high in healthy controls (ρ = 0.80 ± 0.04), but showed a significant 17% reduction (p < 0.05) in aMCI/AD patients (ρ = 0.67 ± 0.05). Positive across-subject correlations were overall moderate (ρ = 0.33 ± 0.07) and consistent across rs-fMRI metrics. These were confined around AD-target posterior regions for metrics of functional connectivity (ReHo and gICA-DR). In contrast, FDG/fALFF correlations were distributed in the frontal gyrus, thalami and caudate nuclei. Taken together, these results support the presence of bioenergetic coupling between glucose utilization and rapid transmission of neural information in healthy ageing, which is substantially reduced in aMCI/AD, suggesting that abnormal glucose utilization is in some way linked to communication breakdown among brain regions impacted by the underlying pathological process.

Original languageEnglish
Pages (from-to)246-258
Number of pages13
JournalNeuroImage
Volume176
DOIs
Publication statusPublished - Aug 1 2018

Fingerprint

Alzheimer Disease
Magnetic Resonance Imaging
Glucose
Caudate Nucleus
Brain
Pathologic Processes
Neurosciences
Thalamus
Synaptic Transmission
Energy Metabolism
Communication
Head
Control Groups

Keywords

  • Alzheimer disease
  • Brain functional MRI
  • Default mode network
  • Fludeoxyglucose PET
  • Intrinsic functional connectivity
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease : Relationship between glucose metabolism and intrinsic activity. / Marchitelli, Rocco; Aiello, Marco; Cachia, Arnaud; Quarantelli, Mario; Cavaliere, Carlo; Postiglione, Alfredo; Tedeschi, Gioacchino; Montella, Patrizia; Milan, Graziella; Salvatore, Marco; Salvatore, Elena; Baron, Jean Claude; Pappatà, Sabina.

In: NeuroImage, Vol. 176, 01.08.2018, p. 246-258.

Research output: Contribution to journalArticle

Marchitelli, R, Aiello, M, Cachia, A, Quarantelli, M, Cavaliere, C, Postiglione, A, Tedeschi, G, Montella, P, Milan, G, Salvatore, M, Salvatore, E, Baron, JC & Pappatà, S 2018, 'Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity', NeuroImage, vol. 176, pp. 246-258. https://doi.org/10.1016/j.neuroimage.2018.04.048
Marchitelli, Rocco ; Aiello, Marco ; Cachia, Arnaud ; Quarantelli, Mario ; Cavaliere, Carlo ; Postiglione, Alfredo ; Tedeschi, Gioacchino ; Montella, Patrizia ; Milan, Graziella ; Salvatore, Marco ; Salvatore, Elena ; Baron, Jean Claude ; Pappatà, Sabina. / Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease : Relationship between glucose metabolism and intrinsic activity. In: NeuroImage. 2018 ; Vol. 176. pp. 246-258.
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