Simvastatin but not pravastatin inhibits the proliferation of rat aorta myocytes

A. Corsini; M. Raiteri; M. Soma; R. Fumagalli; R. Paoletti

doi:10.1016/S1043-6618(05)80119-7

Simvastatin but not pravastatin inhibits the proliferation of rat aorta myocytes

A. Corsini, M. Raiteri, M. Soma, R. Fumagalli, R. Paoletti

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

The in vitro effect of simvastatin and pravastatin, two competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on the proliferation of rat aortic smooth muscle cells was investigated. Simvastatin, but not pravastatin, inhibited the replication of arterial myocytes in concentrations ranging between 0.01 μm and 10 μm. The inhibition, evaluated as cell number and nuclear incorporation of [³H]thymidine, was dose-dependent and completely prevented by addition of mevalonate (100 μm), confirming the role of mevalonate or its products in regulating cell division and growth. The present results provide evidence that simvastatin, in addition to its effect on cholesterol biosynthesis, interferes in vitro with other processes involved in atherogenesis.

Original language	English
Pages (from-to)	173-180
Number of pages	8
Journal	Pharmacological Research
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/S1043-6618(05)80119-7
Publication status	Published - 1991

ASJC Scopus subject areas

Pharmacology

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title = "Simvastatin but not pravastatin inhibits the proliferation of rat aorta myocytes",

abstract = "The in vitro effect of simvastatin and pravastatin, two competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on the proliferation of rat aortic smooth muscle cells was investigated. Simvastatin, but not pravastatin, inhibited the replication of arterial myocytes in concentrations ranging between 0.01 μm and 10 μm. The inhibition, evaluated as cell number and nuclear incorporation of [3H]thymidine, was dose-dependent and completely prevented by addition of mevalonate (100 μm), confirming the role of mevalonate or its products in regulating cell division and growth. The present results provide evidence that simvastatin, in addition to its effect on cholesterol biosynthesis, interferes in vitro with other processes involved in atherogenesis.",

author = "A. Corsini and M. Raiteri and M. Soma and R. Fumagalli and R. Paoletti",

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T1 - Simvastatin but not pravastatin inhibits the proliferation of rat aorta myocytes

AU - Corsini, A.

AU - Raiteri, M.

AU - Soma, M.

AU - Fumagalli, R.

AU - Paoletti, R.

PY - 1991

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AB - The in vitro effect of simvastatin and pravastatin, two competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on the proliferation of rat aortic smooth muscle cells was investigated. Simvastatin, but not pravastatin, inhibited the replication of arterial myocytes in concentrations ranging between 0.01 μm and 10 μm. The inhibition, evaluated as cell number and nuclear incorporation of [3H]thymidine, was dose-dependent and completely prevented by addition of mevalonate (100 μm), confirming the role of mevalonate or its products in regulating cell division and growth. The present results provide evidence that simvastatin, in addition to its effect on cholesterol biosynthesis, interferes in vitro with other processes involved in atherogenesis.

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