Abstract
The in vitro effect of simvastatin and pravastatin, two competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on the proliferation of rat aortic smooth muscle cells was investigated. Simvastatin, but not pravastatin, inhibited the replication of arterial myocytes in concentrations ranging between 0.01 μm and 10 μm. The inhibition, evaluated as cell number and nuclear incorporation of [3H]thymidine, was dose-dependent and completely prevented by addition of mevalonate (100 μm), confirming the role of mevalonate or its products in regulating cell division and growth. The present results provide evidence that simvastatin, in addition to its effect on cholesterol biosynthesis, interferes in vitro with other processes involved in atherogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 173-180 |
| Number of pages | 8 |
| Journal | Pharmacological Research |
| Volume | 23 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Pharmacology
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Simvastatin but not pravastatin inhibits the proliferation of rat aorta myocytes. / Corsini, A.; Raiteri, M.; Soma, M.; Fumagalli, R.; Paoletti, R.
In: Pharmacological Research, Vol. 23, No. 2, 1991, p. 173-180.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simvastatin but not pravastatin inhibits the proliferation of rat aorta myocytes
AU - Corsini, A.
AU - Raiteri, M.
AU - Soma, M.
AU - Fumagalli, R.
AU - Paoletti, R.
PY - 1991
Y1 - 1991
N2 - The in vitro effect of simvastatin and pravastatin, two competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on the proliferation of rat aortic smooth muscle cells was investigated. Simvastatin, but not pravastatin, inhibited the replication of arterial myocytes in concentrations ranging between 0.01 μm and 10 μm. The inhibition, evaluated as cell number and nuclear incorporation of [3H]thymidine, was dose-dependent and completely prevented by addition of mevalonate (100 μm), confirming the role of mevalonate or its products in regulating cell division and growth. The present results provide evidence that simvastatin, in addition to its effect on cholesterol biosynthesis, interferes in vitro with other processes involved in atherogenesis.
AB - The in vitro effect of simvastatin and pravastatin, two competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on the proliferation of rat aortic smooth muscle cells was investigated. Simvastatin, but not pravastatin, inhibited the replication of arterial myocytes in concentrations ranging between 0.01 μm and 10 μm. The inhibition, evaluated as cell number and nuclear incorporation of [3H]thymidine, was dose-dependent and completely prevented by addition of mevalonate (100 μm), confirming the role of mevalonate or its products in regulating cell division and growth. The present results provide evidence that simvastatin, in addition to its effect on cholesterol biosynthesis, interferes in vitro with other processes involved in atherogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0026081431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026081431&partnerID=8YFLogxK
U2 - 10.1016/S1043-6618(05)80119-7
DO - 10.1016/S1043-6618(05)80119-7
M3 - Article
C2 - 1905808
AN - SCOPUS:0026081431
VL - 23
SP - 173
EP - 180
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 2
ER -