Simvastatin but not pravastatin inhibits the proliferation of rat aorta myocytes

A. Corsini, M. Raiteri, M. Soma, R. Fumagalli, R. Paoletti

Research output: Contribution to journalArticlepeer-review

Abstract

The in vitro effect of simvastatin and pravastatin, two competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on the proliferation of rat aortic smooth muscle cells was investigated. Simvastatin, but not pravastatin, inhibited the replication of arterial myocytes in concentrations ranging between 0.01 μm and 10 μm. The inhibition, evaluated as cell number and nuclear incorporation of [3H]thymidine, was dose-dependent and completely prevented by addition of mevalonate (100 μm), confirming the role of mevalonate or its products in regulating cell division and growth. The present results provide evidence that simvastatin, in addition to its effect on cholesterol biosynthesis, interferes in vitro with other processes involved in atherogenesis.

Original languageEnglish
Pages (from-to)173-180
Number of pages8
JournalPharmacological Research
Volume23
Issue number2
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Pharmacology

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