Simvastatin down-regulates the production of Interleukin-8 by neutrophil leukocytes from dyslipidemic patients

Franca Marino, Andrea M. Maresca, Luana Castiglioni, Marco Cosentino, Ramona C. Maio, Laura Schembri, Catherine Klersy, Christian Mongiardi, Laura Robustelli Test, Anna M. Grandi, Luigina Guasti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Neutrophil (PMN) leukocytes participate to the initial phases of atherosclerosis through the release of Interleukin 8 (CxCL8; IL-8) that contribute to amplification of inflammation. Aim of the study is to investigate the production of IL-8 by PMN leukocytes from dyslipidemic patients treated with simvastatin.Methods: In 15 dyslipidemic subjects with moderately increased cardiovascular risk, assessed by Framingham Risk Score, blood samples were obtain to investigate PMNs IL-8 production [at baseline and after N-formyl-Met-Leu-Phe (fMLP) stimulation] before and after long-term (1-year) simvastatin treatment.Results: The resting release of IL-8 was higher in dyslipidemic patients at baseline when compared with control subjects (p <0.05). One year of treatment was significantly associated with reduced IL-8 production (p <0.01). Moreover, the fMLP-induced IL-8 production in dyslipidemic untreated patients was higher than that of controls (p <0.05) and was reduced after simvastatin treatment (p <0.01). IL-8 release after 1 year of treatment was reduced to levels which were lower than those observed in control subjects both for resting and stimulated cytokine production (p <0.01).Conclusions: Prolonged treatment with simvastatin is associated with a reduction of IL-8 production, suggesting the possibility of statin to modulate the pro-inflammatory response in PMNs of patients with moderately increased cardiovascular risk.

Original languageEnglish
Article number37
JournalBMC Cardiovascular Disorders
Volume14
DOIs
Publication statusPublished - Mar 15 2014

Keywords

  • Dyslipidemia
  • Interleukin-8
  • Neutrophils
  • Statin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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