Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering

Stephanie H. Wilson, Joerg Herrmann, Lilach O. Lerman, David R. Holmes, Claudio Napoli, Erik L. Ritman, Amir Lerman

Research output: Contribution to journalArticle

Abstract

Background - Previous studies have demonstrated that experimental hypercholesterolemia leads to neovascularization in the coronary artery vasa vasorum (VV). Recent evidence suggests that HMG-CoA reductase inhibitors (statins) have beneficial effects independent of lipid lowering. We aimed to determine the effect of simvastatin on coronary VV neovascularization, in the absence of cholesterol lowering. Methods and Results - Pigs were randomized to 3 groups fed a normal (N), high cholesterol (HC), or HC + simvastatin (HC+S) diet for 12 weeks. The proximal left anterior descending artery was isolated, scanned with micro-CT, and reconstructed. Quantification of the VV density in serial cross-sections along the vessel was then performed. LDL cholesterol was similarly increased in HC and HC+S compared with N. There was an increase in both VV density (4.7±0.3 versus 2.7±0.2 n/mm2; P2; P2; P2; P

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalCirculation
Volume105
Issue number4
DOIs
Publication statusPublished - Jan 29 2002

Keywords

  • Hypercholesterolemia
  • Pathological neovascularization
  • Statins

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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